Febuxostat
更新时间：2023-09-20 10:31:41
| 常用名 | 非布索坦 | CAS号 | 144060-53-7 |
|---|---|---|---|
| 价格 | ￥需询单/1kg ￥需询单/1g ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Febuxostat(TEI 6720;TMX 67 ) is selective xanthine oxidase inhibitor with Ki of 0.6 nM.IC50 value: 0.6 nM (Ki) [1]Target: xanthine oxidasein vitro: Febuxostat displays potent mixed-type inhibition of the activity of purified bovine milk xanthine oxidase, with Ki and Ki' values of 0.6 nM and 3.1 nM respectively, indicating inhibition of both the oxidized and reduced forms of xanthine oxidase [1]. in vivo: Febuxostat (5–6 mg/kg/day) combined with fructose significantly lowers blood pressure, UA, triglycerides, and insulin in rats compared with fructose alone. Febuxostat (5–6 mg/kg/day) combined with fructose also reduces glomerular pressure, renal vasoconstriction, and afferent arteriolar area in rats compared with fructose alone [2]. Febuxostat prevents hyperuricemia in 5/6 nephrectomy (5/6 Nx)+oxonic acid (OA)+Febuxostat(Fx) rats and ameliorates proteinuria, preserves renal function and prevents glomerular hypertension in both 5/6 nephrectomy (5/6 Nx)+vehicle (V)+Febuxostat(Fx) and 5/6 nephrectomy (5/6 Nx)+oxonic acid (OA)+Febuxostat(Fx) groups [3]. Febuxostat (5 mg/kg/d by gavage for 8 days) treatment after transverse aortic constriction (TAC) attenuates the TAC-induced left ventricular (LV) hypertrophy and dysfunction. Febuxostat blunts the TAC-induced increases in nitrotyrosine (indicating reduced myocardial oxidative stress), p-Erk(Thr202/Tyr204), and p-mTOR(Ser2488), with no effect on total Erk or total mTOR [4]. 物理化学性质： CAS号：144060-53-7 常用中文名：非布索坦 常用英文名：Febuxostat 分子式：C16H16N2O3S 分子量：316.375 密度：1.3±0.1 g/cm3 沸点：536.6±60.0 °C at 760 mmHg 熔点：238-239ºC 闪点：278.3±32.9 °C 储存条件：Refrigerator |
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：非布索坦
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
- 广东翁江化学试剂有限公司
- 广东省 韶关市 翁源县
- 产品名：非布索坦
- 价格： ￥4000.0/500g ￥3200.0/500g
- 纯度：99.0%
- 备货期：需询单
- 联系人：朱丽丹
- 武汉敬康恩生物医药科技有限公司
- 湖北省 武汉市 东西湖区
- 产品名：Febuxostat
- 价格： ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：周经理
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参考价格：$66/10mM*1mLinDMSO