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Ipragliflozin

更新时间:2024-03-06 22:54:45

常用名 伊格列净 CAS号 761423-87-4
价格 ¥需询单/1kg ¥需询单/1g ¥需询单/1mg 纯度 98.0%
备货期 需询单 库存 询单
 产品详情(用途,包装等)
用途:
Ipragliflozin (ASP1941) is a highly potent and selective SGLT2 inhibitor with IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6.IC50 value: 2.8 nM [1][2]Target: SGLT2in vitro: Ipragliflozin potently and selectively inhibited human, rat, and mouse SGLT2 at nanomolar ranges and exhibited stability against intestinal glucosidases [3].in vivo: Ipragliflozin showed good pharmacokinetic properties following oral dosing, and dose-dependently increased urinary glucose excretion, which lasted for over 12 h in normal mice [3]. Oral administration of ipragliflozin increased urinary glucose excretion in a dose-dependent manner, an effect which was significant at doses of 0.3 mg/kg or higher and lasted over 12 h [4]. Single administration of ipragliflozin dose-dependently increased urinary glucose excretion, reduced blood glucose and plasma insulin levels, and improved glucose intolerance [5].
物理化学性质:
CAS号:761423-87-4
常用中文名:伊格列净
常用英文名:Ipragliflozin
分子式:C21H21FO5S
分子量:404.452
密度:1.5±0.1 g/cm3
沸点:628.8±55.0 °C at 760 mmHg
熔点:N/A
闪点:334.1±31.5 °C
储存条件:-20℃

供应商信息

上海楼岚生物科技有限公司

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