AST1306
更新时间：2024-01-16 16:12:59
| 常用名 | 艾力替尼 | CAS号 | 1050500-29-2 |
|---|---|---|---|
| 价格 | ￥需询单/1kg ￥需询单/1g ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Allitinib tosylate (AST-1306 TsOH) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.IC50 value: 0.5/3 nM (EGFR/Erb2)[1]Target: EGFR/Erb2;Mutant EGFR T790M/L858RAllitinib functions as an irreversible inhibitor, most likely through covalent interaction with Cys797 and Cys805 in the catalytic domains of EGFR and ErbB2, respectively. Further studies showed that Allitinib inactivated pathways downstream of these receptors and thereby inhibited the proliferation of a panel of cancer cell lines. Allitinib is a potent(pM) and selective inhibitor of EGFR and ErbB4 (IC50 = 500pM and 800 pM, respectively). AST-1306 blocks phosphorylation of EGFR and also prevents downstream pathways. Allitinib also dose-dependently inhibits EGF-induced EGFR phosphorylation in the A549 cancer cell line. 物理化学性质： CAS号：1050500-29-2 常用中文名：艾力替尼 常用英文名：AST-1306 (TsOH) 分子式：C31H26ClFN4O5S 分子量：621.078 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：室温，干燥，密封 |
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：AST-1306
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：N-[4-[[3-氯-4-[(3-氟苯基)甲氧基]苯基]氨基]-6-喹唑啉基]-2-丙烯酰胺对甲苯磺酸盐
- 价格： ￥1472.9/10mg ￥969.9/5mg ￥2300.9/1ml ￥5149.9/50mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$246/10mM*1mLinDMSO