BIBS39
更新时间：2023-09-26 15:44:11
| 常用名 | BIBS 39 | CAS号 | 133085-33-3 |
|---|---|---|---|
| 价格 | ￥需询单/1kg ￥需询单/1g ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist.Target: Angiotensin Receptorin vitro: BIBS 39 displaces [125I] AII from its specific binding sites with a Ki value of 29 ± 7 nM for the AII subtype 1 (AT1) receptor and a Ki value of 480 ± 110 nM for the AII subtype 2 (AT2) receptor. BIBS 222 shows a Ki value of 20 ± 7 nM for the AT1 subtype and a Ki value of 730 ± 170 nM for the AT2 subtype. BIBS 39 is 17 times more selective for the AT1 subtype and BIBS 222 37 times. BIBS 39 shifts the AII concentration-contractile response curves in isolated rabbit aorta to the right in a parallel fashion. [1]in vivo: In pithed rats, BIBS 39 dependently shifts the dose-response curve of AII to the right without affecting the maximal response. BIBS 222 also causes parallel shifts to the right but a significant reduction of the maximal responses was observed at 3 and 10 mg/kg i.v. These results show that the benzimidazole derivatives BIBS 39 is a potent and selective AII receptor antagonists. Substitution with a benzimidazole moiety results into a considerable loss of selectivity for the AT1 receptor subtype compared with an imidazole moiety as, for instance, in DuP 753.[1] BIBS 39 is a new nonpeptide angiotensin receptor blockers that has affinity for both AT1- and AT2-receptors, is also a potent antagonist of the cardiovascular effects of AII in pithed rabbits. [2] 物理化学性质： CAS号：133085-33-3 常用中文名：BIBS 39 常用英文名：BIBS 39 分子式：C32H36N4O3 分子量：524.65300 密度：1.24g/cm3 沸点：729.1ºC at 760 mmHg 熔点：N/A 闪点：394.8ºC 储存条件：2-8℃ |
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：BIBS39
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：BIBS 39
- 价格： ￥2729.9/10mg ￥4579.9/25mg ￥746.9/1mg ￥1529.9/5mg
- 纯度：98.0%
- 备货期：10天
- 联系人：阿拉丁
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参考价格：$291/10mM*1mLinDMSO