YHO13177
更新时间：2024-04-01 16:52:04
| 常用名 | YHO-13177 | CAS号 | 912287-56-0 |
|---|---|---|---|
| 价格 | ￥需询单/1g ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： YHO-13177 is a potent and specific inhibitor of BCRP; potentiated the cytotoxicity of SN-38 in cancer cells and no effect on P-glycoprotein–mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells.IC50 value:Target: BCRP inhibitorin vitro: YHO-13177 potentiated the cytotoxicity of SN-38, mitoxantrone, and topotecan in both BCRP-transduced human colon cancer HCT116 (HCT116/BCRP) cells and SN-38–resistant human lung cancer A549 (A549/SN4) cells that express BCRP, but had little effect in the parental cells. In addition, YHO-13177 potentiated the cytotoxicity of SN-38 in human lung cancer NCI-H460 and NCI-H23, myeloma RPMI-8226, and pancreatic cancer AsPC-1 cells that intrinsically expressed BCRP. In contrast, it had no effect on P-glycoprotein–mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells and multidrug resistance-related protein 1–mediated doxorubicin resistance in MRP1-transfected human epidermoid cancer KB-3-1 cells. YHO-13177 increased the intracellular accumulation of Hoechst 33342, a substrate of BCRP, at 30 minutes and partially suppressed the expression of BCRP protein at more than 24 hours after its treatment in both HCT116/BCRP and A549/SN4 cells [1].in vivo: In mice, YHO-13351 was rapidly converted into YHO-13177 after its oral or intravenous administration. Coadministration of irinotecan with YHO-13351 significantly increased the survival time of mice inoculated with BCRP-transduced murine leukemia P388 cells and suppressed the tumor growth in an HCT116/BCRP xenograft model, whereas irinotecan alone had little effect in these tumor models [1]. 物理化学性质： CAS号：912287-56-0 常用中文名：YHO-13177 常用英文名：YHO-13177 分子式：C20H22N2O3S 分子量：370.46500 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8℃ |
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：YHO-13177
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿摩尔生物科技有限公司
- 上海市 上海市 奉贤区
- 产品名：YHO-13177游离态
- 价格： ￥需询单/100mg ￥需询单/10mg ￥需询单/1g ￥需询单/1mg
- 纯度：99.0%
- 备货期：需询单
- 联系人：王汐瑶
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：YHO-13177
- 价格： ￥7209.9/100mg ￥2622.9/25mg ￥792.9/5mg ￥需询单/100g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$134/10mM*1mLinDMSO