PF04418948
更新时间：2024-01-11 16:33:05
| 常用名 | PF-04418948 | CAS号 | 1078166-57-0 |
|---|---|---|---|
| 价格 | ￥需询单/1g ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： PF-04418948 is a novel, potent and selective prostaglandin EP2 receptor antagonist with IC50 of 16 nM, displays >2000-fold functional selectivity for the human EP2 receptor over antagonist activity against the human EP1, EP3, EP4, DP1 and CRTH2 receptors.IC50 value: 16 nMTarget: EP2in vitro: PF-04418948 inhibits prostaglandin E2 (PGE2)-induced increase in cAMP in cells expressing EP2 receptors with a functional KB value of 1.8 nM. In human myometrium, PF-04418948 produced a parallel, rightward shift of the butaprost-induced inhibition of the contractions induced by electrical field stimulation with an apparent KB of 5.4 nM. [1]in vivo: In dog bronchiole and mouse trachea, PF-04418948 produced parallel rightward shifts of the PGE2-induced relaxation curve with a KB of 2.5 nM and an apparent KB of 1.3 nM respectively. Reversal of the PGE2-induced relaxation in the mouse trachea by PF-04418948 produced an IC50 value of 2.7 nM. Given orally, PF-04418948 attenuated the butaprost-induced cutaneous blood flow response in rats. [1] PF-04418948 competitively inhibits relaxations of murine and guinea pig trachea induced by ONO-AE1-259 and PGE2 respectively.[2] 物理化学性质： CAS号：1078166-57-0 常用中文名：PF-04418948 常用英文名：PF 04418948 分子式：C23H20FNO5 分子量：409.407 密度：1.4±0.1 g/cm3 沸点：639.1±55.0 °C at 760 mmHg 熔点：N/A 闪点：340.3±31.5 °C 储存条件：-20℃ |
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：PF 04418948
- 价格： ￥822.9/1ml ￥4531.9/100mg ￥823.9/10mg ￥1802.9/25mg
- 纯度：99.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$77/10mM*1mLinDMSO