MM102
更新时间：2024-09-26 18:56:27
| 常用名 | 1-[[(2S)-5-[(氨基亚胺甲基)氨基]-2-[[2-乙基-2-[(2-甲基-1-氧代丙基)氨基]-1-氧代丁基]氨基]-1-氧代戊基]氨基]-N-[二(4-氟苯基)甲基]环戊烷甲酰胺] | CAS号 | 1417329-24-8 |
|---|---|---|---|
| 价格 | ￥需询单/1g ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： MM-102 is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM with an estimated Ki 200 times more potent than the ARA peptide.IC50 value: 2.4 nMTarget: MLLin vitro: MM-102 inhibits MLL1 methyltransferase activity and MLL-1-induced HoxA9 and Meis-1 gene expression in leukemia cells expressing the MLL1-AF9 fusion gene. Also inhibits cell growth and induces apoptosis in leukemia cells harbouring MLL1 fusion proteins. MM-102, with the highest binding affinities to WDR5, also show the most potent inhibitory activity in the HMT assay with IC50 = 0.4-0.9 μM. MM-102 dose-dependently inhibits cell growth in the MV4;11 and KOPN8 leukemia cell lines, which carry MLL1-AF4 and MLL1-ENL fusion proteins, respectively. MM-102 has IC50 = 25 μM in both cell lines and completely inhibits cell growth in these cell lines at 75 μM. MM-102 effectively and selectively inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins and has minimal effect in leukemia cells with wild-type MLL1 protein.[1] 物理化学性质： CAS号：1417329-24-8 常用中文名：1-[[(2S)-5-[(氨基亚胺甲基)氨基]-2-[[2-乙基-2-[(2-甲基-1-氧代丙基)氨基]-1-氧代丁基]氨基]-1-氧代戊基]氨基]-N-[二(4-氟苯基)甲基]环戊烷甲酰胺] 常用英文名：MM-102 分子式：C35H49F2N7O4 分子量：669.80500 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：-20℃ |
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：MM-102
- 价格： ￥1544.9/10mg ￥618.9/3mg ￥1029.9/5mg ￥2875.9/1ml
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：MM-102
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
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1-[[(2S)-5-[(氨基亚胺甲基)氨基]-2-[[2-乙基-2-[(2-甲基-1-氧代丙基)氨基]-1-氧代丁基]氨基]-1-氧代戊基]氨基]-N-[二(4-氟苯基)甲基]环戊烷甲酰胺]生产厂家
参考价格：$60/2mg