亚叶酸钙
更新时间：2024-04-23 09:56:55
| 常用名 | 亚叶酸钙 | CAS号 | 1492-18-8 |
|---|---|---|---|
| 价格 | ￥需询单/1kg ￥需询单/1g | 纯度 | 98.0% |
| 备货期 | 3天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Leucovorin Calcium is a reduced folic acid.IC50 Value: 30 μM for zcSHMT and70 μM for zmSHMT [2]Target: Antifolatein vitro: Increasing concentrations of leucovorin (N5-CHO-THF) inhibit both zcSHMT and hcSHMT activities substantially, yet to a lesser extent than zmSHMT. The IC50 of leucovorin is approximately 30 μM for zcSHMT and higher than 70 μM for zmSHMT. The differential inhibition is evident with the presence of 10 μM leucovorin, the concentration estimated in serum in a high-dose leucovorin rescue regimen [2].in vivo: Following intravenous administration, peak plasma concentrations of (6R) LV, (6S) LV, and 5-CH3 THF were 148 +/- 32, 59.1 +/- 22, and 17.8 +/- 17 microM, respectively. During oral administration of LV, virtually no (6S) LV appeared in the plasma. Steady-state plasma concentrations of (6R) LV and 5-CH3 THF were approximately 1.5 +/- 0.23 and 2.8 +/- 0.41 microM, respectively [1]. 24 fasted subjects were given 4 of a series of 5 single test doses between 20 and 100 mg, at 1-week intervals, of 5-formyl-THF as an oral solution of leucovorin calcium. Six separate subjects received 200 mg iv and po in a 2-way crossover. Blood and urine samples were collected over 24 hours for differential microbiological folate assays using Lactobacillus casei and Streptococcus faecalis. Using L casei activity to measure total serum folates, the area under the concentration-time curve from 0 to infinite time (AUC[0-infinity]) was calculated. Relative bioavailabilities were 78%, 62%, 49%, and 42% for the 40-, 60-, 80-, and 100-mg doses, respectively [3].Clinical trial: Leucovorin and Fluorouracil With or Without SU-5416 in Treating Patients With Metastatic Colorectal Cancer . Phase 3 物理化学性质： CAS号：1492-18-8 常用中文名：亚叶酸钙 常用英文名：Folinic acid (Calcium) 分子式：C20H21CaN7O7 分子量：511.501 密度：N/A 沸点：N/A 熔点：240-250ºC 闪点：N/A 储存条件：存放于惰性气体之中;避免光,湿气 (吸湿) |
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：亚叶酸钙盐水合物
- 价格： ￥194.9/1g ￥82.9/250mg ￥2399.9/25g ￥599.9/5g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：亚叶酸钙,水合物
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
- 上海吉至生化科技有限公司
- 上海市 上海市 奉贤区
- 产品名：亚叶酸钙,水合物
- 价格： ￥278.0/1g
- 纯度：98.0%
- 备货期：3天
- 联系人：刘佳
- 中山市迪欣化工有限公司
- 广东省 中山市 三角镇
- 产品名：亚叶酸钙
- 价格： ￥6030.0/25kg
- 纯度：99.0%
- 备货期：3天
- 联系人：董生
- 中山星瑞化工有限公司
- 广东省 中山市 中山火炬高技术产业开发区
- 产品名：亚叶酸钙
- 价格： ￥需询单/25kg
- 纯度：99.0%
- 备货期：需询单
- 联系人：王经理
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参考价格：￥385/100mg