| 常用名 | 联苯苄唑 | CAS号 | 60628-96-8 |
|---|---|---|---|
| 价格 | ¥需询单/1kg ¥需询单/1g | 纯度 | 98.0% |
| 备货期 | 3天 | 库存 | 现货 |
| 产品详情(用途,包装等)
用途: Bifonazole is an imidazole antifungal drug.Target: AntifungalBifonazole, a new broad-spectrum antimycotic, interferes with sterol biosynthesis. In dermatophytes bifonazole additionally inhibits directly HMG-CoA-reductase. bifonazole possesses a sequential mode of action, namely inhibition of cytochrome P450-dependent C14-demethylation of sterols and direct inhibition of HMG-CoA-reductase. In vitro bifonazole shows a strongly pH-dependent efficacy. The uptake kinetics of bifonazole have been measured with different pathogens [1]. Bifonazole additionally leads to a generally decreased rate of sterol biosynthesis as compared to clotrimazole, due to a direct inhibition of microsomal HMG-CoA-reductase. The additional fungicidal effects of bifonazole are considered to originate from a sequential action by inhibition of HMG-CoA-reductase and of cytochrome P450 [2]. bifonazole were affected by choice of medium with Kimmig's agar generally giving the lowest MIC's. Bifonazole MICs were shown to vary with pH (maximal activity at pH 6 . 5) with selected yeasts when tested on Kimmig's agar [3]. 物理化学性质: CAS号:60628-96-8 常用中文名:联苯苄唑 常用英文名:Bifonazole 分子式:C22H18N2 分子量:310.392 密度:1.1±0.1 g/cm3 沸点:491.7±24.0 °C at 760 mmHg 熔点:142℃ 闪点:251.2±22.9 °C 储存条件:通风低温干燥 |