艾替班特
更新时间：2024-05-30 16:54:21
| 常用名 | 艾替班特 | CAS号 | 130308-48-4 |
|---|---|---|---|
| 价格 | $需询单/1mg $需询单/100kg | 纯度 | 98.0% |
| 备货期 | 1天 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Icatibant(HOE-140) is a selective and specific antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively.IC50 value: 1.07 nM [1]Target: bradykinin B2 receptor antgonistin vitro: In receptor binding studies in guinea-pig ileum preparations, Hoe 140 showed an IC50 of 1.07 x 10(-9) mol l-1 and a KI value of 7.98 x 10(-10) mol l-1. In isolated organ preparations Hoe 140 and D-Arg-[Hyp2,Thi5,8, D-Phe7]BK inhibited bradykinin-induced contractions concentration dependently, with IC50-values in the guinea-pig ileum preparation of 1.1 x 10(-8) mol l-1 and 3 x 10(-5) mol l-1, respectively. pA2 values in this tissue were 8.42 and 6.18, respectively [1].in vivo: HOE 140 (1, 3, or 10 μg/10 μl physiological saline) was administered into the wound by a sterile micropipette. HOE 140 (1, 3, 10 μg) significantly relieved mechanical allodynia and guarding in comparison with vehicle-treated group [2]. HOE-140 (10 nmol/kg) protected against memory impairment. This treatment attenuated the brain edema, interleukin-1β, tumor necrosis factor-α, and nitric oxide metabolites content elicited by mLFPI. Accordingly, HOE-140 administration protected against the increase of nicotinamide adenine dinucleotide phosphate oxidase activity, thiobarbituric-acid-reactive species, protein carbonylation generation, and Na+ K+ ATPase inhibition induced by trauma [3]. 物理化学性质： CAS号：130308-48-4 常用中文名：艾替班特 常用英文名：HOE 140 TFA 分子式：C59H89N19O13S 分子量：1304.522 密度：1.6±0.1 g/cm3 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：−20°C |
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：艾替班特
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
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参考价格：$1119/10mM*1mLinDMSO