| 常用名 | 富马酸水合酶-IN-1 | CAS号 | 1644060-37-6 |
|---|---|---|---|
| 价格 | ¥需询单/1g | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 现货 |
| 产品详情(用途,包装等)
用途: Fumarate hydratase-IN-1, an enzyme of the TCA cycle. Inhibition of fumarate hydratase-IN-1 can contribute to tumorigenicity in some cells. The use of a photoaffinity labeling strategy identified fumarate hydratase as the principal pharmacological target.[1]In vitro: The activity of this enzyme was measured using a well-established assay that monitored the conversion of fumarate into L-malate and subsequent oxidation of L-malate to oxaloacetate by malate dehydrogenase. Initial controls established that neither the carboxylic acid 3 nor ester 2 inhibited malate dehydrogenase Using this two-enzyme protocol we found that carboxylic acid 3 inhibited fumarate hydratase in a dose-dependent fashion in vitro. Besides, inhibition of fumarate hydratase can contribute to tumorigenicity in some cells.[1] 物理化学性质: CAS号:1644060-37-6 常用中文名:富马酸水合酶-IN-1 常用英文名:Fumarate hydratase-IN-1 分子式:C27H30N2O4 分子量:446.538 密度:1.2±0.1 g/cm3 沸点:693.0±55.0 °C at 760 mmHg 熔点:N/A 闪点:372.9±31.5 °C 储存条件:2-8℃ |