LED209游离态
更新时间：2024-07-15 12:34:08
采购访问：15次
| 常用名 | N-苯基-4-(3-苯基硫代脲基)苯磺酰胺 | CAS号 | 245342-14-7 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： LED209 is a potent small molecule inhibitor of bacterial receptor QseC, is a potent prodrug that is highly selective for QseC. Target: AntibacterialLED209 has desirable pharmacokinetics and does not present toxicity in vitro and in rodents. This is a unique antivirulence approach, with a proven broad-spectrum activity against multiple Gram-negative pathogens that cause mammalian infections.The LED209 QseC inhibitor has a unique mode of action by acting as a prodrug scaffold to deliver a warhead that allosterically modifies QseC, impeding virulence in several Gram-negative pathogens.[1] LED209 is QseC sensor kinase inhibitor , as a potential lead compound to combat infections with Legionella or Mycobacterium spp. [2] LED209 inhibits the binding of signals to QseC, preventing its autophosphorylation and consequently inhibiting QseC-mediated activation of virulence gene expression. LED209 inhibits EHEC virulence traits in vitro. LED209 markedly inhibits the virulence of several pathogens in animals. Inhibition of signaling offers a strategy for the development of broad-spectrum antimicrobial drugs. [3] 物理化学性质： CAS号：245342-14-7 常用中文名：N-苯基-4-(3-苯基硫代脲基)苯磺酰胺 常用英文名：LED209 分子式：C19H17N3O2S2 分子量：383.487 密度：1.4±0.1 g/cm3 沸点：549.4±60.0 °C at 760 mmHg 熔点：N/A 闪点：286.1±32.9 °C 储存条件：2-8℃ |
上海念兴实业有限公司
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- 上海阿拉丁生化科技股份有限公司
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- 产品名：LED209
- 价格： ￥508.0/5mg ￥需询单/1g ￥需询单/1g ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$60/5mg