| 常用名 | 7-丁基-6-(4-羟基苯基)-5H-吡咯并[2,3-B]吡嗪 | CAS号 | 496864-16-5 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情(用途,包装等)
用途: Aloisine A (RP107) is a a potent cyclin-dependent kinase (CDK) inhibitor with IC50s of 0.15 μM, 0.12 μM, 0.4 μM, 0.16 μM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK5/p35, respectively. Aloisine A ininhibits GSK-3α (IC50=0.5 µM) and GSK-3β (IC50=1.5 µM). Aloisine A stimulates wild-type CFTR and mutated CFTR, with submicromolar affinity by a cAMP-independent mechanism. Aloisine A has the potential for CFTR-related diseases, including cystic fibrosis research[1][2]. 物理化学性质: CAS号:496864-16-5 常用中文名:7-丁基-6-(4-羟基苯基)-5H-吡咯并[2,3-B]吡嗪 常用英文名:Aloisine A 分子式:C16H17N3O 分子量:267.32600 密度:1.227g/cm3 沸点:N/A 熔点:281-283ºC 闪点:N/A |