PNRI-299?
更新时间：2024-07-15 12:35:44
采购访问：3次
| 常用名 | PNRI-299 | CAS号 | 550368-41-7 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： PNRI-299 is a selective AP-1 transcription inhibitor with IC50 of 20 uM without affecting NF-kappaB transcription (up to 200 uM) or thioredoxin (up to 200 uM).IC50 value: 20 uM [1]Target: AP-1 inhibitorin vitro: PNRI-299 specifically reacts with Ref-1, inhibits AP-1 transcription, and overexpression of the molecular target. Ref-1 attenuates PNRI-299 inhibition of AP-1 transcription. PNRI-299 interacts with the redox nucleophile Cys-65, to aid in the interpretation of structure activity relationships (SARs).in vivo: Treatment with PNRI-299 significantly decreased the influx of eosinophils, monocytes, and macrophages (no significant reduction of lymphocytes was observed) into the lung interstitium and bronchoalveolar lavage fluid, and airway mucus and edema observed in OVA-treated mice.PNRI-299 reduces the pathophysiological responses seen in this murine model of allergic asthma [1]. PNRI-299 had no effects on the inflammatory changes or lethality induced by I/R injury [2]. 物理化学性质： CAS号：550368-41-7 常用中文名：PNRI-299 常用英文名：PNRI-299 分子式：C21H15N5O4 分子量：401.37 密度：1.5±0.1 g/cm3 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8℃ |
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