BR-001
更新时间：2024-07-17 16:20:39
采购访问：16次
| 常用名 | BR-001 | CAS号 | 2356113-28-3 |
|---|---|---|---|
| 价格 | ￥需询单/100mg ￥需询单/250mg ￥需询单/1g | 纯度 | 98.0% |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： BR-001 (BR001) is a potent, selective, allosteric inhibitor of EED subunit of PRC2 complex, disrupts EED-H3K27me3 interaction (IC50=4.5 nM).BR-001 directly binds to EED in the H3K27me3-binding pocket, BR-001 significantly increases the thermal stability of EED in thermal shift assay.BR-001 is selective for EED, has no activity against 371 wild-type kinases.BR-001 significantly reduced the cellular H3K27me3 level and also exhibited a strong antiproliferative effect in Karpas 422 cells.BR-001 inhibited proliferation of DLBCL cells and tumor growth, and upregulated target genes expression.BR-001 has potent antitumor efficacy in vivo, modulates immune response to suppress syngeneic CT26 colon tumor. 物理化学性质： CAS号：2356113-28-3 常用中文名：BR-001 常用英文名：BR-001 分子式：C20H17D2FN4O2 分子量：368.409 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A |
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