常用名 | 肌苷 | CAS号 | 58-63-9 |
---|---|---|---|
价格 | ¥需询单/25kg | 纯度 | 99.0% |
备货期 | 需询单 | 库存 | 3 |
产品详情(用途,包装等)
用途: Inosine, an endogenous purine nucleoside, has immunomodulatory, neuroprotective, and analgesic properties. In vitro: Inosine has been shown to stimulate axonal growth in cell culture and promote corticospinal tract axons to sprout collateral branches after stroke, spinal cord injury and TBI in rodent models.[1] Inosine dose-dependently stimulates cAMP production mediated through the A2AR. Inosine dose-dependently induces A2AR-mediated ERK1/2 phosphorylation.[2] In vivo: The reference for Inosine is 1 or 10 mg/kg, i.p. Preventive treatment with inosine inhibits the development and progression of EAE in C57Bl/6 mice. neuroinflammation and demyelinating processes are blocked by inosine treatment. Additionally, inosine consistently inhibits IL-17 levels in peripheral lymphoid tissue, as well as IL-4 levels and A2AR up-regulation in the spinal cord, likely, through an ERK1-independent pathway. [3] inosine acting through adenosine receptors (ARs) exerts a wide range of anti-inflammatory and immunomodulatory effects in vivo. [2] 物理化学性质: CAS号:58-63-9 常用中文名:肌苷 常用英文名:Inosine 分子式:C10H12N4O5 分子量:268.226 密度:2.1±0.1 g/cm3 沸点:670.5±65.0 °C at 760 mmHg 熔点:222-226 °C (dec.)(lit.) 闪点:359.3±34.3 °C 储存条件:室温,干燥,密封 |