| 常用名 | 氢溴酸槟榔碱 | CAS号 | 300-08-3 |
|---|---|---|---|
| 价格 | ¥需询单/1kg | 纯度 | 98.0% |
| 备货期 | 2天 | 库存 | 现货 |
| 产品详情(用途,包装等)
用途: Arecoline Hydrobromide is a muscarinic acetylcholine receptor agonist. Target: mAChRArecoline is an alkaloid found in the areca nut. Arecoline. a drug obtained from the Areca Catechu L., induced a dose-dependent antinociception (0.3-1 mg kg(-1) i.p.) which was prevented by the muscarinic antagonists pirenzepine (0.1 microg per mouse i.c.v.) and S-(-)-ET-126 (0.01 microg per mouse i.c.v.) [1]. Arecoline exerts its excitatory actions by binding to M2-muscarinic receptors on the cell membrane of neurons of the locus coeruleus [2]. Arecoline (1 nM - 1 microM) produced a concentration-dependent contraction in both the longitudinal and the circular smooth muscle of rabbit colon. Atropine (10 microM) abolished the arecoline (80 nM)--induced contraction. M3 receptor antagonist, 4 - DAMP (0.4 microM), abolished the arecoline (80 nM)--related response, whereas M2 receptor antagonist, gallamine (0.4 microM), did not affect the effect of arecoline. These results suggest that arecoline excites the colonic motility via M3 receptor in rabbits [3]. 物理化学性质: CAS号:300-08-3 常用中文名:氢溴酸槟榔碱 常用英文名:Arecoline hydrobromide 分子式:C8H14BrNO2 分子量:236.106 密度:N/A 沸点:209ºC at 760mmHg 熔点:171-175 °C 闪点:81.1ºC 储存条件:Refrigerator |