| 常用名 | 宝藿苷II | CAS号 | 55395-07-8 |
|---|---|---|---|
| 价格 | ¥2400.0/5mg ¥需询单/100mg | 纯度 | 98.0% |
| 备货期 | 3天 | 库存 | 900 mg |
| 产品详情(用途,包装等)
用途: IKarisoside A(Icarisoside-A) is a natural compound isolated from Epimedium koreanum (Berberidaceae); has anti-inflammatory properties.IC50 value:Target: in vitro: Ikarisoside A inhibited the expression of LPS-stimulated inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells and mouse bone marrow-derived macrophages (BMMs) in a concentration-dependent manner. In addition, Ikarisoside A reduced the release of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta). Furthermore, Ikarisoside A inhibited the activity of p38 kinase and nuclear factor-kappaB (NF-kappaB) [1]. Ikarisoside A is a potent inhibitor of osteoclastogenesis in RANKL-stimulated RAW 264.7 cells as well as in bone marrow-derived macrophages.The inhibitory effect of Ikarisoside A resulted in decrease of osteoclast-specific genes like matrix metalloproteinase 9 (MMP9), tartrate-resistant acid phosphatase (TRAP), receptor activator of NF-kappaB (RANK), and cathepsin K. Moreover, Ikarisoside A blocked the resorbing capacity of RAW 264.7 cells on calcium phosphate-coated plates. Ikarisoside A also has inhibitory effects on the RANKL-mediated activation of NF-kappaB, JNK, and Akt [2]. 物理化学性质: CAS号:55395-07-8 常用中文名:宝藿苷II 常用英文名:Baohuoside II 分子式:C26H28O10 分子量:500.495 密度:1.5±0.1 g/cm3 沸点:782.1±60.0 °C at 760 mmHg 熔点:N/A 闪点:264.7±26.4 °C 储存条件:2-8℃ |