华蟾素
更新时间：2024-08-21 12:13:37
| 常用名 | 华蟾毒它灵 | CAS号 | 1108-68-5 |
|---|---|---|---|
| 价格 | ￥需询单/20mg | 纯度 | 98.0% |
| 备货期 | 1天 | 库存 | 900 mg |
| 产品详情（用途，包装等）
用途： Cinobufotalin is one of the bufadienolides prepared from toad venom; has anticancer activity.IC50 value:Target:in vitro: Cinobufotalin(CB) caused significant DNA fragmentation, decrease of MMP, and an increase in the intracellular Ca(2+) ion and ROS production. In addition, CB induced upregulation of Fas protein, proteolytic activation of cytochrome c, caspase-2, -3, -8 and -9 together with the activation of Bid and Bax [1]. cinobufotalin displayed considerable cytotoxicity against lung cancer cells (A549, H460 and HTB-58 lines) without inducing significant cell apoptosis. cinobufotalin mainly induces Cyp-D-dependent non-apoptotic death in cultured lung cancer cells [2]. cinobufotalin (at nmol/L) significantly inhibited HCC cell growth and survival while inducing considerable cell apoptosis. Further, cinobufotalin inhibited sphingosine kinase 1 (SphK1) activity and induced pro-apoptotic ceramide production. cinobufotalin inactivated Akt-S6K1 signaling in HepG2 cells, which was again inhibited by ceramide synthase-1 shRNA-depletion [3].in vivo: Using a mice xenograft model, we found that cinobufotalin inhibited A549 lung cancer cell growth in vivo [2]. 作用： 1、抗肿瘤作用 2、免役促进作用 3、抗病毒作用 物理化学性质： CAS号：1108-68-5 常用中文名：华蟾毒它灵 常用英文名：Cinobufotalin 分子式：C26H34O7 分子量：458.544 密度：1.3±0.1 g/cm3 沸点：627.3±55.0 °C at 760 mmHg 熔点：259 - 262ºC 闪点：210.7±25.0 °C 储存条件：2-8°C |
- 上海吉至生化科技有限公司
- 上海市 上海市 奉贤区
- 产品名：华蟾毒它灵
- 价格： ￥1108.0/5mg ￥2158.0/20mg
- 纯度：98.0%
- 备货期：1天
- 联系人：刘佳
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：Cinobufotalin
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
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参考价格：$119/10mM*1mLinDMSO