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Regulation of immunopathology in hepatitis B virus infection
10.1038/nm.3873 2015-06-04 In the liver there is a fine balance between immune surveillance of blood-borne infections and regulation of immunopathology. A new study identifies a role for granulocytic myeloid-derived suppressor cells in limiting T cell–mediated immunopathology in hepati... |
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Biomedical briefing
10.1038/nm0615-546 2015-06-04
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Binding time—not just affinity—gains stature in drug design
10.1038/nm0615-545 2015-06-04
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Microbiome models, on computers and in lab dishes, see progress
10.1038/nm0615-543 2015-06-04
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New consent requirements for newborn screening raise concerns
10.1038/nm0615-542 2015-06-04
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Updated, augmented vaccines compete with original antigenic sin
10.1038/nm0615-540 2015-06-04
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Let research bloom
10.1038/nm.3879 2015-06-04 Recent news of raids on research budgets illustrates how precarious government funding of scientific research has become. In an era of unprecedented momentum in the development of technologies and therapies for studying and treating disease, opportunities for... |
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Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients
10.1038/nm.3870 2015-06-01 By monitoring cfDNA, the authors reveal the dynamic adaption of clonal populations in colorectal cancer patients treated with anti-EGFR therapy, suggesting that therapeutic re-challenge may have some benefit. |
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Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR
10.1038/nm.3863 2015-06-01 Epigenetic inactivation of a Rab GTPase activating protein confers metastatic properties in melanoma, and it correlates with poor prognosis but better sensitivity to therapy by targeting EGFR signaling. |
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Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL.
Nat. Med. 21 , 563-71, (2015) 2015-06-01 Relapse is the leading cause of mortality in children with acute lymphoblastic leukemia (ALL). Among chemotherapeutics, thiopurines are key drugs in ALL combination therapy. Using whole-exome sequencing, we identified relapse-specific mutations in the phospho... |