|
Nanoparticles administered intrapericardially enhance payload myocardial distribution and retention
10.1016/j.jconrel.2017.07.012 2017-07-09 Pharmacological therapies for cardiovascular diseases are limited by short-term pharmacokinetics and extra-cardiac adverse effects. Improving delivery selectivity specifically to the heart, wherein therapeutic drug levels can be maintained over time, is highl... |
|
|
In vivo induction of regulatory T cells promotes allergen tolerance and suppresses allergic contact dermatitis
10.1016/j.jconrel.2017.07.006 2017-07-08 Allergic contact dermatitis (ACD) is a common T-cell mediated inflammatory skin condition, characterized by an intensely pruritic rash at the site of contact with allergens like poison ivy or nickel. Current clinical treatments use topical corticosteroids, wh... |
|
|
Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential
10.1016/j.jconrel.2017.07.007 2017-07-08 Chronic skin wounds affect ≈ 3% of persons aged > 60 years (Davies et al., 2007) [1]. These wounds are typically difficult to heal by conventional therapies and in many cases they get infected making even harder the regeneration process. The antimicrobial pep... |
|
|
Ultrasound targeted CNS gene delivery for Parkinson's disease treatment
10.1016/j.jconrel.2017.07.004 2017-07-08 Parkinson's disease (PD) is a potent neurodegenerative disease in which a progressive loss of dopaminergic neurons eventually produces a loss of movement control and other symptoms. To date, in addition to pharmacological, non-pharmacological, and neurosurgic... |
|
|
Drug depot-anchoring hydrogel: A self-assembling scaffold for localized drug release and enhanced stem cell differentiation
10.1016/j.jconrel.2017.07.008 2017-07-08 Localized and long-term delivery of growth factors has been a long-standing challenge for stem cell-based tissue engineering. In the current study, a polymeric drug depot-anchoring hydrogel scaffold was developed for the sustained release of macromolecules to... |
|
|
Medical capsule robots: A renaissance for diagnostics, drug delivery and surgical treatment
10.1016/j.jconrel.2017.07.005 2017-07-08 The advancements in electronics and the progress in nanotechnology have resulted in path breaking development that will transform the way diagnosis and treatment are carried out currently. This development is Medical Capsule Robots, which has emerged from the... |
|
|
Biodegradable brain-penetrating DNA nanocomplexes and their use to treat malignant brain tumors
10.1016/j.jconrel.2017.07.009 2017-07-08 The discovery of powerful genetic targets has spurred clinical development of gene therapy approaches to treat patients with malignant brain tumors. However, lack of success in the clinic has been attributed to the inability of conventional gene vectors to ac... |
|
|
Polymer conjugated retinoids for controlled transdermal delivery
10.1016/j.jconrel.2017.07.003 2017-07-06 All-trans retinoic acid (ATRA), a derivative of vitamin A, is a common component in cosmetics and commercial acne creams as well as being a first-line chemotherapeutic agent. Today, formulations for the topical application of ATRA rely on creams and emulsions... |
|
|
Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases
10.1016/j.jconrel.2017.07.001 2017-07-04 Extracellular vesicles (EVs) are cell-derived membrane vesicles virtually secreted by all cells, including brain cells. EVs are a major term that includes apoptotic bodies, microvesicles and exosomes. The release of EVs has been recognized as an important mod... |
|
|
A potential non-invasive glioblastoma treatment: Nose-to-brain delivery of farnesylthiosalicylic acid incorporated hybrid nanoparticles
10.1016/j.jconrel.2017.06.032 2017-07-03 New drug delivery systems are highly needed in research and clinical area to effectively treat gliomas by reaching a high antineoplastic drug concentration at the target site without damaging healthy tissues. Intranasal (IN) administration, an alternative rou... |