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Build/couple/pair strategy combining the Petasis 3-component reaction with Ru-catalyzed ring-closing metathesis and isomerization. ACS Comb. Sci. 4th ed., 14 , 253-257, (2012) 2012-04-09 A "build/couple/pair" pathway for the systematic synthesis of structurally diverse small molecules is presented. The Petasis 3-component reaction was used to synthesize anti-amino alcohols displaying pairwise reactive combinations of alkene moieties. Upon tre...
Visual monitoring of solid-phase extraction using chromogenic fluorous synthesis supports. ACS Comb. Sci. 14(3) , 150-4, (2012) 2012-03-12 Reductive aminations and further transformations of an azo dye and fluorous tagged aldehyde are described. The intensely colored 2,4-dialkoxybenzyl protected amines undergo Fmoc-based peptide coupling, Suzuki reactions, and sulfonamide formation with product ...
Combinatorial pulsed laser deposition of Fe, Cr, Mn, and Ni-substituted SrTiO3 films on Si substrates. ACS Comb. Sci. 14(3) , 179-90, (2012) 2012-03-12 Combinatorial pulsed laser deposition (CPLD) using two targets was used to produce a range of transition metal-substituted perovskite-structured Sr(Ti(1-x)M(x))O(3-δ) films on buffered silicon substrates, where M = Fe, Cr, Ni and Mn and x = 0.05-0.5. CPLD pro...
Microwave-assisted linear approach toward highly substituted benzo[d]oxazol-5-yl-1H-benzo[d]imidazole on ionic liquid support. ACS Comb. Sci. 14(2) , 115-23, (2012) 2012-02-13 A novel and efficient diversity-oriented synthetic approach was employed to access the benzo[d]oxazol-5-yl-1H-benzo[d]imidazole on ionic liquid support, which helps to absorb microwave irradiation. In this paper, we successfully coupled 4-hydroxy-3-nitrobenzo...
Efficient one-pot, three-component synthesis of a library of pyrrolo[1,2-c]pyrimidine derivatives. ACS Comb. Sci. 14(2) , 101-7, (2012) 2012-02-13 Herein is reported a simple and efficient one-pot three-component synthesis of pyrrolo[1,2-c]pyrimidine derivatives starting from various substituted pyrimidines, 2-bromoacetophenones, and electron deficient alkynes in epoxides acting both as reaction medium ...
I2-mediated diversity oriented diastereoselective synthesis of amino acid derived trans-2,5-disubstituted morpholines, piperazines, and thiomorpholines. ACS Comb. Sci. 14(1) , 1-4, (2012) 2012-01-09 Diastereoselective trans-2,5-disubstituted amino acids derived diverse morpholines, piperazines and thiomorpholines were prepared in 30 min-1 h with high yields through iodine-mediated 6-exotrig type cyclization from a single common synthetic intermediate. Th...
Pseudo-five-component reaction between 3-formylchromones, meldrum's acid, isocyanides and primary arylamines: diversity-oriented synthesis of novel chromone-containing peptidomimetics. ACS Comb. Sci. 13(6) , 659-66, (2011) 2011-11-14 An efficient and practical method has been developed for the diversity-oriented synthesis of chromone-containing tripeptides via pseudo-five-component reaction between 3-formylchromones, Meldrum's acid, isocyanides and primary aromatic amines for the generati...
Microplates with adaptive surfaces. ACS Comb. Sci. 13(6) , 646-52, (2011) 2011-11-14 Here we present a new and versatile method for the modification of the well surfaces of polystyrene microtiter plates (microplates) with poly(N-phenylethylene diamine methacrylamide), (poly-NPEDMA). The chemical grafting of poly-NPEDMA to the surface of micro...
Solid-phase synthesis of smac peptidomimetics incorporating triazoloprolines and biarylalanines. ACS Comb. Sci. 6th ed., 13 , 667-675, (2011) 2011-11-14 Apoptotic induction mechanisms are of crucial importance for the general homeostasis of multicellular organisms. In cancer the apoptotic pathways are downregulated, which, at least partly, is due to an abundance of inhibitors of apoptosis proteins (IAPs) that...
Fluorescence-based high throughput screening for noble metal-free and platinum-poor anode catalysts for the direct methanol fuel cell. ACS Comb. Sci. 13 , 518-529, (2011) 2011-09-12 We describe here the results of a high throughput screening study for direct methanol fuel cell (DMFC) anode catalysts consisting of new elemental combinations with an optical high-throughput screening method, which allows the quantitative evaluation of the e...

Build/couple/pair strategy combining the Petasis 3-component reaction with Ru-catalyzed ring-closing metathesis and isomerization.

ACS Comb. Sci. 4th ed., 14 , 253-257, (2012)

2012-04-09

A "build/couple/pair" pathway for the systematic synthesis of structurally diverse small molecules is presented. The Petasis 3-component reaction was used to synthesize anti-amino alcohols displaying pairwise reactive combinations of alkene moieties. Upon tre...

Visual monitoring of solid-phase extraction using chromogenic fluorous synthesis supports.

ACS Comb. Sci. 14(3) , 150-4, (2012)

2012-03-12

Reductive aminations and further transformations of an azo dye and fluorous tagged aldehyde are described. The intensely colored 2,4-dialkoxybenzyl protected amines undergo Fmoc-based peptide coupling, Suzuki reactions, and sulfonamide formation with product ...

Combinatorial pulsed laser deposition of Fe, Cr, Mn, and Ni-substituted SrTiO3 films on Si substrates.

ACS Comb. Sci. 14(3) , 179-90, (2012)

2012-03-12

Combinatorial pulsed laser deposition (CPLD) using two targets was used to produce a range of transition metal-substituted perovskite-structured Sr(Ti(1-x)M(x))O(3-δ) films on buffered silicon substrates, where M = Fe, Cr, Ni and Mn and x = 0.05-0.5. CPLD pro...

Microwave-assisted linear approach toward highly substituted benzo[d]oxazol-5-yl-1H-benzo[d]imidazole on ionic liquid support.

ACS Comb. Sci. 14(2) , 115-23, (2012)

2012-02-13

A novel and efficient diversity-oriented synthetic approach was employed to access the benzo[d]oxazol-5-yl-1H-benzo[d]imidazole on ionic liquid support, which helps to absorb microwave irradiation. In this paper, we successfully coupled 4-hydroxy-3-nitrobenzo...

Efficient one-pot, three-component synthesis of a library of pyrrolo[1,2-c]pyrimidine derivatives.

ACS Comb. Sci. 14(2) , 101-7, (2012)

2012-02-13

Herein is reported a simple and efficient one-pot three-component synthesis of pyrrolo[1,2-c]pyrimidine derivatives starting from various substituted pyrimidines, 2-bromoacetophenones, and electron deficient alkynes in epoxides acting both as reaction medium ...

I2-mediated diversity oriented diastereoselective synthesis of amino acid derived trans-2,5-disubstituted morpholines, piperazines, and thiomorpholines.

ACS Comb. Sci. 14(1) , 1-4, (2012)

2012-01-09

Diastereoselective trans-2,5-disubstituted amino acids derived diverse morpholines, piperazines and thiomorpholines were prepared in 30 min-1 h with high yields through iodine-mediated 6-exotrig type cyclization from a single common synthetic intermediate. Th...

Pseudo-five-component reaction between 3-formylchromones, meldrum's acid, isocyanides and primary arylamines: diversity-oriented synthesis of novel chromone-containing peptidomimetics.

ACS Comb. Sci. 13(6) , 659-66, (2011)

2011-11-14

An efficient and practical method has been developed for the diversity-oriented synthesis of chromone-containing tripeptides via pseudo-five-component reaction between 3-formylchromones, Meldrum's acid, isocyanides and primary aromatic amines for the generati...

Microplates with adaptive surfaces.

ACS Comb. Sci. 13(6) , 646-52, (2011)

2011-11-14

Here we present a new and versatile method for the modification of the well surfaces of polystyrene microtiter plates (microplates) with poly(N-phenylethylene diamine methacrylamide), (poly-NPEDMA). The chemical grafting of poly-NPEDMA to the surface of micro...

Solid-phase synthesis of smac peptidomimetics incorporating triazoloprolines and biarylalanines.

ACS Comb. Sci. 6th ed., 13 , 667-675, (2011)

2011-11-14

Apoptotic induction mechanisms are of crucial importance for the general homeostasis of multicellular organisms. In cancer the apoptotic pathways are downregulated, which, at least partly, is due to an abundance of inhibitors of apoptosis proteins (IAPs) that...

Fluorescence-based high throughput screening for noble metal-free and platinum-poor anode catalysts for the direct methanol fuel cell.

ACS Comb. Sci. 13 , 518-529, (2011)

2011-09-12

We describe here the results of a high throughput screening study for direct methanol fuel cell (DMFC) anode catalysts consisting of new elemental combinations with an optical high-throughput screening method, which allows the quantitative evaluation of the e...