10.1038/s41551-017-0082

2017-06-05

The ability to detect biomarkers with ultrahigh sensitivity radically transformed biology and disease diagnosis. However, owing to incompatibilities with infrastructure in current biological and medical laboratories, recent innovations in analytical technolog...

10.1038/s41551-017-0078

2017-06-05

Stimulation of the glucagon-like peptide-1 (GLP1) receptor is a useful treatment strategy for type 2 diabetes due to pleiotropic effects, such as the regulation of islet hormones and the induction of satiety. However, the native ligand for the GLP1 receptor h...

10.1038/s41551-017-0072

2017-05-10

Drug delivery: Closed-loop dynamic dosing Nature Biomedical Engineering, Published online: 10 May 2017; doi:10.1038/s41551-017-0072 A system consisting of an aptamer-based microfluidic biosensor and a simple feedback-control algorithm adjusts therapeutic dosi...

10.1038/s41551-017-0075

2017-05-10

Photoacoustic tomography: Breathtaking whole-body imaging Nature Biomedical Engineering, Published online: 10 May 2017; doi:10.1038/s41551-017-0075 High-frame-rate, high-resolution photoacoustic computed tomography reveals, for small live animals, the brain's...

10.1038/s41551-017-0068

2017-05-10

Imaging plays a critical role in the diagnosis and assessment of dermatological conditions. However, optical or optoacoustic microscopy techniques are limited to visualizing superficial skin features owing to strong photon scattering, whereas ultrasound metho...

10.1038/s41551-017-0074

2017-05-10

Organs-on-chips: Filtration enabled by differentiation Nature Biomedical Engineering, Published online: 10 May 2017; doi:10.1038/s41551-017-0074 The efficient generation of mature podocytes from induced pluripotent stem cells makes possible the recapitulation...

10.1038/s41551-017-0070

2017-05-10

Current methods of drug dosing rely on physical parameters (such as sex, age and weight) that do not account for genetic and physiological differences among individual patients. These differences can greatly affect how drugs are processed in the body and can ...

10.1038/s41551-017-0073

2017-05-10

Neuroprosthetics: Restoring multi-joint motor control Nature Biomedical Engineering, Published online: 10 May 2017; doi:10.1038/s41551-017-0073 An intracortical brain–computer interface combined with functional electrical stimulation allows an individual with...

10.1038/s41551-017-0066

2017-05-10

Cpf1, a type-V CRISPR–Cas effector endonuclease, exhibits gene-editing activity in human cells through a single RNA-guided approach. Here, we report the design and assessment of an array of 42 types of engineered Acidaminococcus sp. Cpf1 (AsCpf1) CRISPR RNA (...

10.1038/s41551-017-0071

2017-05-10

Imaging of small animals has played an indispensable role in preclinical research by providing high-dimensional physiological, pathological and phenotypic insights with clinical relevance. Yet, pure optical imaging suffers from either shallow penetration (up ...