|
Role of Sox9 in Collagen Hydrogel-Mediated Chondrogenic Differentiation of Adult Mesenchymal Stem Cells (MSCs)
10.1039/C8BM00317C 2018-04-11 Sox9 is a transcription factor that regulates chondrogenesis, but its role in chondrogenic differentiation of mesenchymal stem cells (MSCs) triggered by materials is poorly understood. In this study, we investigated the effect of Sox9 interference on collagen... |
|
|
Designing well-defined photopolymerized synthetic matrices for three-dimensional culture and differentiation of induced pluripotent stem cells
10.1039/C8BM00099A 2018-04-10 Induced pluripotent stem cells (iPSCs) are of interest for the study of disease, where these cells can be derived from patients and have the potential to be differentiated into any cell type; however, three-dimensional (3D) culture and differentiation of iPSC... |
|
|
Injectable self-assembled peptide hydrogels for glucose-mediated insulin delivery
10.1039/C8BM00006A 2018-04-06 Closed-loop glucose-responsive insulin delivery with excellent biocompatibility has the potential to improve the health and quality of life of diabetic patients. Herein, we developed an excellent glucose-responsive insulin delivery system using a pH-sensitive... |
|
|
Polytyrosine nanoparticles enable ultra-high loading of doxorubicin and rapidly enzyme-responsive drug release
10.1039/C8BM00243F 2018-04-06 In spite of great significance, few clinically viable nanovehicles possess stable and high anticancer drug loading while fast intracellular drug release. Here, we report that polytyrosine nanoparticles (PTNs) self-assembled from poly(ethylene glycol)-b- poly(... |
|
|
Maintenance of the spheroid organization and properties of glandular progenitor cells by fabricated chitosan based biomaterials
10.1039/C7BM00559H 2018-04-05 Dysfunctional salivary gland (SG) is an unsolved clinical challenge, which is presented as xerostomia. Cell therapy is a promising treatment for restoring SG function. Salispheres are spheroid cellular organizations derived from SG stem cells. Benefitting fro... |
|
|
Mitochondria-Targeted Zirconium Metal-Organic Frameworks for Enhancing Microwave Thermal Therapy Against Tumor
10.1039/C8BM00142A 2018-04-05 Although microwave (MW) thermal therapy has been widely studied for the treatment of tumors due to its less invasiveness, the recurrence of tumors is still observed because of the relatively low bioavailability of MW sensitizers. For enhancing the bioavailabi... |
|
|
Chitosan-catechol: A writable bioink under serum culture media
10.1039/C8BM00174J 2018-04-04 Mussel-inspired multifunctional coatings on biomedical devices have been a great interest due to its unique property, such as substrate indendency and high efficiency. The key molecules for mussel-inspired adhesive coatings are catechol and amine groups. Alon... |
|
|
Impact of substrate stiffness on dermal papilla aggregates in microgels
10.1039/C8BM00248G 2018-03-29 Interaction between cells and extracellular environment plays a vital role in cellular development. The mechanical property of a 3-dimensional (3D) culture can be modified to mimic in-vivo conditions. Dermal Papilla (DP) cells are shown to gradually lose thei... |
|
|
Targeted delivery of tungsten oxide nanoparticles for multifunctional anti-tumor therapy via macrophages
10.1039/C8BM00218E 2018-03-29 Tumor-associated macrophages are highly versatile effector cells that have been used to kill tumor cells. Herein, the macrophages as cell-based biocarriers are used for the targeted delivery of photothermal reagents for promoting the efficiency of killing tum... |
|
|
Multivalent conjugates of basic fibroblast growth factor enhance in vitro proliferation and migration of endothelial cells
10.1039/C7BM01052D 2018-03-27 Growth factors hold great promise for regenerative therapies. However, their clinical use has been halted by poor efficacy and rapid clearance from tissue, necessitating the delivery of extremely high doses to achieve clinical effectiveness which has raised s... |