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Energetics: an emerging frontier in cellular mechanosensing: Reply to comments on “Cellular Mechanosensing of the Biophysical Microenvironment: A Review of Mathematical Models of Biophysical Regulation of Cell Responses”

10.1016/j.plrev.2017.09.003

2017-09-29

How do cells can sense the substrate stiffness? Our recent review highlighted a range of theoretical models and simulations that have been proposed to answer this important question. In response to this review, three leading groups in the field noted some imp...

Answering Schrödinger's question: A free-energy formulation

10.1016/j.plrev.2017.09.001

2017-09-20

The free-energy principle (FEP) is a formal model of neuronal processes that is widely recognised in neuroscience as a unifying theory of the brain and biobehaviour. More recently, however, it has been extended beyond the brain to explain the dynamics of livi...

Modeling human behavior in economics and social science

10.1016/j.plrev.2017.06.026

2017-06-29

The complex interactions between human behaviors and social economic sciences is critically analyzed in this paper in view of possible applications of mathematical modeling as an attainable interdisciplinary approach to understand and simulate the aforementio...

Generalizing dependency distance: Comment on “Dependency distance: A new perspective on syntactic patterns in natural languages” by Haitao Liu et al.

10.1016/j.plrev.2017.06.023

2017-06-23

With the support of the comprehensive review in Liu et al. [14], we consider dependency distance minimization to be firmly established as a quantitative property of syntactic trees. In this comment, we consider future empirical and theoretical directions for ...

Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses

10.1016/j.plrev.2017.06.016

2017-06-21

Cells in vivo reside within complex microenvironments composed of both biochemical and biophysical cues. The dynamic feedback between cells and their microenvironments hinges upon biophysical cues that regulate critical cellular behaviors. Understanding this ...

Ligand diffusion in proteins via enhanced sampling in molecular dynamics

10.1016/j.plrev.2017.03.003

2017-04-01

Computational simulations in biophysics describe the dynamics and functions of biological macromolecules at the atomic level. Among motions particularly important for life are the transport processes in heterogeneous media. The process of ligand diffusion ins...

Dependency distance: A new perspective on syntactic patterns in natural languages

10.1016/j.plrev.2017.03.002

2017-03-27

Dependency distance, measured by the linear distance between two syntactically related words in a sentence, is generally held as an important index of memory burden and an indicator of syntactic difficulty. Since this constraint of memory is common for all hu...

Topodynamics of metastable brains

10.1016/j.plrev.2017.03.001

2017-03-23

The brain displays both the anatomical features of a vast amount of interconnected topological mappings as well as the functional features of a nonlinear, metastable system at the edge of chaos, equipped with a phase space where mental random walks tend towar...

Move me, astonish me… delight my eyes and brain: The Vienna Integrated Model of top-down and bottom-up processes in Art Perception (VIMAP) and corresponding affective, evaluative, and neurophysiological correlates

10.1016/j.plrev.2017.02.003

2017-02-27

This paper has a rather audacious purpose: to present a comprehensive theory explaining, and further providing hypotheses for the empirical study of, the multiple ways by which people respond to art. Despite common agreement that interaction with art can be b...

There and back again: Two views on the protein folding puzzle

10.1016/j.plrev.2017.01.025

2017-01-27

The ability of protein chains to spontaneously form their spatial structures is a long-standing puzzle in molecular biology. Experimentally measured folding times of single-domain globular proteins range from microseconds to hours: the difference (10–11 order...