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Glycyrrhiza uralensis and Semilicoisoflavone B Reduce Aβ Secretion by Increasing PPARγ Expression and Inhibiting STAT3 Phosphorylation to Inhibit BACE1 Expression
10.1002/mnfr.201700633 2018-02-23 Glycyrrhiza uralensis extract (GUE) has been reported to improve amyloid beta (Aβ)‐induced cognitive deficits in mice. However, the mechanisms underlying this effect and the components involved have not been previously explored. Extracellular Aβ plaques are o... |
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An extract of Russian Tarragon Prevents Obesity‐Related Ectopic Lipid Accumulation
10.1002/mnfr.201700856 2018-02-23 The primary disorder underlying metabolic syndrome is insulin resistance due to excess body weight and abdominal visceral fat accumulation. In this study, we asked if dietary intake of an ethanolic extract from Russian tarragon (Artemisia dracunculus L., term... |
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Cholesterol Absorption and Synthesis in Vegetarians and Omnivores
10.1002/mnfr.201700689 2018-02-23 Vegetarian diets are considered health‐promoting; however, a plasma cholesterol lowering effect is not always observed. We investigate the link between vegetarian‐diet‐induced alterations in cholesterol metabolism. |
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Hypolipidemic and Antioxidant Properties of Oryzanol Concentrate in Reducing Diabetic Nephropathy via SREBP1 Down Regulation Rather than Beta Oxidation
10.1002/mnfr.201700511 2018-02-22 Diabetic nephropathy (DN) is a micro‐vascular complication of chronic diabetes. Sterol regulatory element binding protein1 (SREBP1) participation in the development of DN is reported. Oryzanol Concentrate (OC) at 0.1 and 0.3% was tested for its antioxidant an... |
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GPCR6A is a Molecular Target for the Natural Products Gallate and EGCG in Green Tea
10.1002/mnfr.201700770 2018-02-21 The molecular mechanisms whereby gallates in green tea exert metabolic effects are poorly understood. |
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Front cover: Plant Polyphenols Stimulate Adhesion to Intestinal Mucosa and Induce Proteome Changes in the Probiotic Lactobacillus acidophilus NCFM
10.1002/mnfr.201870041 2018-02-20 Mol. Nutr. Food Res. 2018, 62, 1700638 DOI: 10.1002/mnfr.201700638 Lactobacillus acidophilus NCFM is a probiotic bacterium, and plant phenolics are prominent secondary metabolites found in foods and beverages, together residing in the gut. The combination of ... |
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Front cover: Bioavailability of Terpenes and Postprandial Effect on Human Antioxidant Potential. An Open-Label Study in Healthy Subjects
10.1002/mnfr.201870031 2018-02-07 Mol. Nutr. Food Res. 2018, 62, 1700751 DOI: 10.1002/mnfr.201700751 The bioavailability of terpenes highly present in foods of plant origin is investigated. Mastiha, a natural medicinal herb of the Mediterranean basin, is administered per os in healthy humans.... |
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Mice Fed a High‐Cholesterol Diet Supplemented with Quercetin‐3‐Glucoside Show Attenuated Hyperlipidemia and Hyperinsulinemia Associated with Differential Regulation of PCSK9 and LDLR in their Liver and Pancreas
10.1002/mnfr.201700729 2018-02-03 : Hepatic LDL receptor (LDLR) and proprotein convertase subtilisin/kexin type 9 (PCSK9) regulate the clearance of plasma LDL‐cholesterol (LDL‐C): LDLR promotes it, and PCSK9 opposes it. These proteins also expressed in pancreatic β cells. Using cultured hepat... |
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Sulforaphane Regulates Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways
10.1002/mnfr.201700737 2018-01-30 Scope To investigate the effect of sulforaphane (SFN) on the abnormal lipid metabolism and underlying mechanisms. Methods and results Models with abnormal lipid metabolism were established both in rats and human hepatocytes. Hepatic steatosis was detected by ... |
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BCAA Metabolism and Insulin Sensitivity – Dysregulated by Metabolic Status?
10.1002/mnfr.201700756 2018-01-29 Abstract Branched-chain amino acids (BCAAs) appear to influence several synthetic and catabolic cellular signaling cascades leading to altered phenotypes in mammals. BCAAs are most notably known to increase protein synthesis through modulating protein transla... |