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Vasoactive effects of stable aqueous suspensions of single walled carbon nanotubes in hamsters and mice.
Nanotoxicology 8(8) , 867-75, (2014) 2014-12-01 Single-walled carbon nanotubes synthesized with iron (Fe-SWCNT) or gadolinium (Gd-SWCNT) show promise as high performance multimodal contrast and drug-delivery agents. Our purpose was to evaluate potential vasoactive effects of SWCNT. Stable aqueous solutions... |
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Minimal oxidation and inflammogenicity of pristine graphene with residence in the lung.
Nanotoxicology 8(8) , 824-32, (2014) 2014-12-01 Two-dimensional graphitic carbon, graphene, is a new form of nanomaterial with great potential in a wide variety of applications. It is therefore crucial to investigate the behaviour of graphene in biological systems to assess potential adverse effects that m... |
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Silver nanoparticle-specific mitotoxicity in Daphnia magna.
Nanotoxicology 8(8) , 833-42, (2014) 2014-12-01 Silver nanoparticles (Ag NPs) are gaining popularity as bactericidal agents in commercial products; however, the mechanisms of toxicity (MOT) of Ag NPs to other organisms are not fully understood. It is the goal of this research to determine differences in MO... |
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Co-assessment of cell cycle and micronucleus frequencies demonstrates the influence of serum on the in vitro genotoxic response to amorphous monodisperse silica nanoparticles of varying sizes.
Nanotoxicology 8(8) , 876-84, (2014) 2014-12-01 Serum proteins have been shown to modulate the cytotoxic and genotoxic responses to nanomaterials. The aim was to investigate the influence of serum on the induction of micronuclei (MN) by nanoparticles (NPs) of different sizes. Therefore, A549 human lung car... |
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Nontoxic impact of PEG-coated gold nanospheres on functional pulmonary surfactant-secreting alveolar type II cells.
Nanotoxicology 8(8) , 813-23, (2014) 2014-12-01 The outstanding properties of gold nanoparticles (NPs) make them very attractive for biomedical applications. In particular, the inhalation route has gained considerable interest as an innovative strategy for diagnosis and treatment of pulmonary diseases. It ... |
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Low-dose gold nanoparticles exert subtle endocrine-modulating effects on the ovarian steroidogenic pathway ex vivo independent of oxidative stress.
Nanotoxicology 8(8) , 856-66, (2014) 2014-12-01 Gold nanoparticles (GNPs) have gained considerable attention for application in science and industry. However, the untoward effects of such particles on female fertility remain unclear. The objectives of this study were to (1) examine the effects of 10-nm GNP... |
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Toxicity and bio-accumulation of inhaled cerium oxide nanoparticles in CD1 mice.
Nanotoxicology 8(7) , 786-98, (2014) 2014-11-01 Male CD1 mice were subjected to nose-inhalation exposure of CeO2 nanoparticles (NPs) for 0, 7, 14 or 28 days with 14 or 28 days of recovery time at an aerosol concentration of 2 mg/m(3). Markers of lung injury and pro-inflammatory cytokines (interleukin-1beta... |
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In vitro toxicity of nanoceria: effect of coating and stability in biofluids.
Nanotoxicology 8(7) , 799-811, (2014) 2014-11-01 Due to the increasing use of nanometric cerium oxide in applications, concerns about the toxicity of these particles have been raised and have resulted in a large number of studies. We report here on the interactions between 7 nm anionically charged cerium ox... |
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Uptake and toxicity of copper oxide nanoparticles in cultured primary brain astrocytes.
Nanotoxicology 8(7) , 775-85, (2014) 2014-11-01 To test for consequences of an exposure of brain cells to copper oxide nanoparticles (CuO-NPs), we synthesised and characterised dimercaptosuccinate-coated CuO-NPs. These particles had a diameter of around 5 nm as determined by transmission electron microscop... |
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Systematic analysis of silver nanoparticle ionic dissolution by tangential flow filtration: toxicological implications.
Nanotoxicology 8(7) , 718-27, (2014) 2014-11-01 In the field of toxicology of nanomaterials, scientists have not clearly determined if the observed toxicological events are due to the nanoparticles (NPs) themselves or the dissolution of ions released into the biophysiological environment or both phenomenon... |