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Application of ω-Transaminases in the Pharmaceutical Industry
10.1021/acs.chemrev.7b00437 2017-12-18 Chiral amines are valuable building blocks for the pharmaceutical industry. ω-TAms have emerged as an exciting option for their synthesis, offering a potential “green alternative” to overcome the drawbacks associated with conventional chemical methods. In thi... |
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Beyond Transcription: Roles of Transcription Factors in Pre-mRNA Splicing
10.1021/acs.chemrev.7b00470 2017-12-18 Whereas individual steps of protein-coding gene expression in eukaryotes can be studied in isolation in vitro, it has become clear that these steps are intimately connected within cells. Connections not only ensure quality control but also fine-tune the gene ... |
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Small Bioactive Peptides for Biomaterials Design and Therapeutics
10.1021/acs.chemrev.7b00522 2017-12-11 This review is aimed to provide a concise yet extensive survey of key short bioactive peptide sequences for a range of applications ranging from biomaterials development to peptides with therapeutic uses. The following are considered: cell adhesion motifs, st... |
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Redox-Tag Processes: Intramolecular Electron Transfer and Its Broad Relationship to Redox Reactions in General
10.1021/acs.chemrev.7b00400 2017-12-08 Explosive growth in the use of open shell reactivity, including neutral radicals and radical ions, in the field of synthetic organic chemistry has been observed in the past decade, particularly since the advent of ruthenium complexes in 2008. These complexes ... |
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Catalytic Organic Reactions in Water toward Sustainable Society
10.1021/acs.chemrev.7b00417 2017-12-08 Traditional organic synthesis relies heavily on organic solvents for a multitude of tasks, including dissolving the components and facilitating chemical reactions, because many reagents and reactive species are incompatible or immiscible with water. Given tha... |
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Sustainable Conversion of Carbon Dioxide: An Integrated Review of Catalysis and Life Cycle Assessment
10.1021/acs.chemrev.7b00435 2017-12-08 CO2 conversion covers a wide range of possible application areas from fuels to bulk and commodity chemicals and even to specialty products with biological activity such as pharmaceuticals. In the present review, we discuss selected examples in these areas in ... |
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Probing Nanoparticle Plasmons with Electron Energy Loss Spectroscopy
10.1021/acs.chemrev.7b00354 2017-12-07 Electron energy loss spectroscopy (EELS) performed in a scanning transmission electron microscope (STEM) has demonstrated unprecedented power in the characterization of surface plasmons. The subangstrom spatial resolution achieved in EELS and its capability o... |
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Dioxygen in Polyoxometalate Mediated Reactions
10.1021/acs.chemrev.7b00444 2017-12-01 In this review article, we consider the use of molecular oxygen in reactions mediated by polyoxometalates. Polyoxometalates are anionic metal oxide clusters of a variety of structures that are soluble in liquid phases and therefore amenable to homogeneous cat... |
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Surface-Plasmon-Driven Hot Electron Photochemistry
10.1021/acs.chemrev.7b00430 2017-11-30 Visible-light-driven photochemistry has continued to attract heightened interest due to its capacity to efficiently harvest solar energy and its potential to solve the global energy crisis. Plasmonic nanostructures boast broadly tunable optical properties cou... |
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From Allylic Sulfoxides to Allylic Sulfenates: Fifty Years of a Never-Ending [2,3]-Sigmatropic Rearrangement
10.1021/acs.chemrev.7b00428 2017-11-29 The [2,3]-sigmatropic rearrangement of allylic sulfoxides to allylic sulfenates is a reversible process, generally shifted toward the sulfoxide. In the presence of thiophiles, the sulfenate is trapped, and allylic alcohols are obtained under mild conditions. ... |