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Encapsulated Optically Responsive Cell Systems: Toward Smart Implants in Biomedicine
10.1002/adhm.201701148 2017-12-28 Abstract Managing increasingly prevalent chronic diseases will require close continuous monitoring of patients. Cell-based biosensors may be used for implantable diagnostic systems to monitor health status. Cells are indeed natural sensors in the body. Functi... |
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Role of the Nucleus as a Sensor of Cell Environment Topography
10.1002/adhm.201701154 2017-12-28 Abstract The proper integration of biophysical cues from the cell vicinity is crucial for cells to maintain homeostasis, cooperate with other cells within the tissues, and properly fulfill their biological function. It is therefore crucial to fully understand... |
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Synthetic Cells Synthesize Therapeutic Proteins inside Tumors
10.1002/adhm.201701163 2017-12-28 Abstract Synthetic cells, artificial cell-like particles, capable of autonomously synthesizing RNA and proteins based on a DNA template, are emerging platforms for studying cellular functions and for revealing the origins-of-life. Here, it is shown for the fi... |
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Tumor Microenvironment-Enabled Nanotherapy
10.1002/adhm.201701156 2017-12-28 Abstract Cancer is now one of the world's leading threats to human health. With the development of oncology in both biology and biomedicine, it has been demonstrated that abnormal physiochemical conditions and dysregulated biosynthetic intermediates in tumor ... |
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Recent Advances in Extrusion-Based 3D Printing for Biomedical Applications
10.1002/adhm.201701161 2017-12-28 Abstract Additive manufacturing, or 3D printing, has become significantly more commonplace in tissue engineering over the past decade, as a variety of new printing materials have been developed. In extrusion-based printing, materials are used for applications... |
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Nanocarrier-Mediated Photochemotherapy and Photoradiotherapy
10.1002/adhm.201701211 2017-12-28 Abstract Photothermal therapy (PTT) and photodynamic therapy (PDT) both utilize light to induce a therapeutic effect. These therapies are rapidly gaining importance due to the noninvasiveness of light and the limited adverse effect associated with these treat... |
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Moldable Hyaluronan Hydrogel Enabled by Dynamic Metal–Bisphosphonate Coordination Chemistry for Wound Healing
10.1002/adhm.201700973 2017-12-27 Abstract Biomaterial-based regenerative approaches would allow for cost-effective off-the-shelf solution for the treatment of wounds. Hyaluronan (HA)-based hydrogel is one attractive biomaterial candidate because it is involved in natural healing processes, i... |
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Convenient Monitoring System of Intracellular microRNA Expression during Adipogenesis via Mechanical Stimulus-Induced Exocytosis of Lipovesicular miRNA Beacon
10.1002/adhm.201701019 2017-12-27 Abstract Noninvasive investigation of microRNAs (miRNAs) expression, which is deeply related to biological phenomena such as stem cell differentiation, in culture soup is particularly useful for monitoring of stem cell differentiation without phototoxicity of... |
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A Fluorescent Biofunctional DNA Hydrogel Prepared by Enzymatic Polymerization
10.1002/adhm.201700998 2017-12-27 Abstract DNA has arisen as a promising building material for the construction of hydrogels owing to its unique properties such as designability and biocompatibility. All-DNA hydrogels with only DNA molecules may have limited applications; hence a composite DN... |
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Fluorination Enhances Serum Stability of Bioreducible Poly(amido amine) Polyplexes and Enables Efficient Intravenous siRNA Delivery
10.1002/adhm.201700978 2017-12-27 Abstract The use of small interfering RNA (siRNA) in cancer treatment has been limited by the lack of effective systemic delivery methods. Although synthetic polycations have been widely explored in siRNA delivery, polycation/siRNA polyplexes often suffer fro... |