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Drimane Sesquiterpenoids Noncompetitively Inhibit Human α4β2 Nicotinic Acetylcholine Receptors with Higher Potency Compared to Human α3β4 and α7 Subtypes
10.1021/acs.jnatprod.7b00893 2018-04-10 The drimane sesquiterpenoids drimenin, cinnamolide, dendocarbin A, and polygodial were purified from the Canelo tree (Drimys winteri) and chemically characterized by spectroscopic methods. The pharmacological activity of these natural compounds were determine... |
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Isolation of Imaqobactin, an Amphiphilic Siderophore from the Arctic Marine Bacterium Variovorax Species RKJM285
10.1021/acs.jnatprod.7b00943 2018-04-04 The amphiphilic siderophore imaqobactin was isolated from the Arctic bacterium Variovorax sp. RKJM285, a strain isolated from marine sediment collected from an inlet near Clyde River, Nunavut, Canada. The 2D structure of imaqobactin was determined by a combin... |
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Bioactive α-Pyrone Derivatives from the Endolichenic Fungus Dothideomycetes sp. EL003334
10.1021/acs.jnatprod.7b01022 2018-04-04 Two new α-pyrones, dothideopyrones E (1) and F (2), were isolated from a culture of the endolichenic fungus Dothideomycetes sp. EL003334. Their structures were elucidated by spectroscopic data analysis. Their absolute configurations were established by the mo... |
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Total Synthesis of Gramistilbenoids A, B, and C
10.1021/acs.jnatprod.7b00865 2018-04-03 Stilbenes are biologically active metabolites of plants that have the potential to attenuate a broad range of human diseases. Gramistilbenoids are a class of natural products with a stilbene skeleton, isolated from the bamboo orchid (Arundina graminifolia), a... |
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Miuramides A and B, Trisoxazole Macrolides from a Mycale sp. Marine Sponge That Induce a Protrusion Phenotype in Cultured Mammalian Cells
10.1021/acs.jnatprod.8b00101 2018-04-03 Morphology-guided cell-based screening of the extract of a Mycale sp. marine sponge led to the isolation of two trisoxazole macrolides, miuramides A (1) and B (2), which induced characteristic morphological changes in 3Y1 cells. The structure of 1 including a... |
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Metabolism of Antifungal Thiochroman-4-ones by Trichoderma viride and Botrytis cinerea
10.1021/acs.jnatprod.7b00298 2018-04-02 Biotransformation of 6-methylthiochroman-4-one (1) and 6-chlorothiochroman-4-one (2) was performed using Trichoderma viride in order to obtain new derivatives with antifungal properties against the phytopathogen Botrytis cinerea. Two thiochromanone derivative... |
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Total Synthesis of (±)-Minfiensine via a Formal [3+2] Cycloaddition
10.1021/acs.jnatprod.7b00873 2018-03-30 (±)-Minfiensine (1) was synthesized in 10 steps in 26% overall yield with the 1,2,3,4-tetrahydro-9a,4a-iminoethanocarbazole core constructed through a [3+2] cycloaddition reaction between indole and an azaoxyallylic cation. |
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Trichorenins A–C, Algicidal Tetracyclic Metabolites from the Marine-Alga-Epiphytic Fungus Trichoderma virens Y13-3
10.1021/acs.jnatprod.8b00164 2018-03-30 Three novel polyketide-like metabolites, trichorenins A–C (1–3), with a unique tetracyclic carbon skeleton were obtained from the culture of Trichoderma virens Y13-3, an epiphyte of the marine red alga Gracilaria vermiculophylla. Their structures and relative... |
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Hepatoprotective Dibenzocyclooctadiene and Tetrahydrobenzocyclooctabenzofuranone Lignans from Kadsura longipedunculata
10.1021/acs.jnatprod.7b00934 2018-03-29 Five new dibenzocyclooctadiene lignans, longipedlignans A–E (1–5), five new tetrahydrobenzocyclooctabenzofuranones (6–10), and 18 known analogues (11–28) were isolated from the roots of Kadsura longipedunculata. Compounds 6–10 are new spirobenzofuranoid–diben... |
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Synthesis and Complete Structure Determination of a Sperm-Activating and -Attracting Factor Isolated from the Ascidian Ascidia sydneiensis
10.1021/acs.jnatprod.7b01052 2018-03-28 For the complete structure elucidation of an endogenous sperm-activating and -attracting factor isolated from eggs of the ascidian Ascidia sydneiensis (Assydn-SAAF), its two possible diastereomers with respect to C-25 were synthesized. Starting from ergostero... |