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POCl3‐Promoted Trifluoromethylthiolation‐based Vicinal Bifunctionalization of Indoles with CF3SO2Na
10.1002/ejoc.201800249 2018-02-22 An efficient trifluoromethylthiolation‐based vicinal bifunctionalization of indoles with sodium trifluoromethanesulfinate in the presence of phosphorus oxychloride were achieved to introduce a chlorine atom into the 2‐position under transition‐metal‐free and ... |
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Base‐Promoted Transition metal‐free Arylation of Imidazo fused Heterocycles with Diaryliodonium salts
10.1002/ejoc.201800286 2018-02-22 Potassium tert‐butoxide promoted arylation of imidazo heterocycles with diaryliodonium salts under transition metal‐free conditions has been described. The reactions proceed through radical pathway without additives and oxidants with good to excellent yields ... |
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Total Synthesis of Catunaregin and Preliminary Evaluation of its Antitumor Activity
10.1002/ejoc.201800219 2018-02-21 Total synthesis of catunaregin in both racemic and optically active forms was accomplished. This enantioselective synthesis employs Evans aldol methodology using oxazolidinone or thiazolidinethione as the chiral auxiliary. The key features include a syn selec... |
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Deacylative Reactions: Synthetic Applications
10.1002/ejoc.201800063 2018-02-21 Herein we introduce the recent developments of a new strategy based on deacylativealkylation (DaA) reactions for the generation of quaternary stereocenters based on the in situ preparation and functionalization of enolates under very mild reaction conditions.... |
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Acid Promoted‐Cascade Cyclization to Produce 2‐(4'‐Alkoxyaryl)‐3,4‐Fused Tricyclic Dihydrobenzopyrans via a Vinylidene para‐Quinone Methide Intermediate
10.1002/ejoc.201800013 2018-02-21 We developed a novel method for synthesizing 2‐(4‐hydroxyaryl)‐3,4‐fused tricyclic dihydrobenzopyrans with 2,3‐syn and 3,4‐syn motif based on the acid‐promoted cascade cyclization via vinylidene para‐quinone methide intermediates. Using easily prepared linear... |
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Luminescent Organogels Generated from Nucleosides Functionalized with Carbazole: Synthesis and Probing for F‐
10.1002/ejoc.201701728 2018-02-20 Novel luminescent organogelators based on nucleoside functionalized with carbazole (UC8, UC12 and UC16) were designed and synthesized. Their gelation ability was tested and it was found that both UC12 and UC16 could form stable organogels in toluene/petroleum... |
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ZnCl2 Catalyzed aza‐Diels‐Alder Reaction for Synthesis of 1H‐Pyrazolo[3,4‐b]pyridine‐4,5‐dicarboxylate Derivatives
10.1002/ejoc.201701761 2018-02-20 A new ZnCl2 catalyzed aza‐Diels‐Alder reaction was developed by using pyrazoylimines with acetylenedicarboxylic acid diethyl ester (diethyl but‐2‐ynedioate) to prepare pyrazolo[3,4‐b]pyridine‐4,5‐dicarboxylate. The key strategy of this reaction was the use of... |
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A Bird's Eye View of Atropisomers Featuring a Five‐Membered Ring
10.1002/ejoc.201800078 2018-02-20 Atropisomers are a subclass of restricted rotational conformers, resulting in a stereogenic sigma bond, which can be isolated as separate chemical species. Most of them concern six‐membered ring biaryl or heterobiaryl derivatives. The aim of this microreview ... |
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Hydrosilylation of Allenes over Palladium‐Gold Alloy Catalysts: Enhancing Activity and Switching Selectivity by the Incorporation of Palladium into Gold Nanoparticles
10.1002/ejoc.201800224 2018-02-20 An efficient synthetic route to alkenylsilanes involving the hydrosilylation of allenes with supported Pd‐Au alloy catalysts has been developed. The incorporation of Pd atoms into Au nanoparticles not only remarkably enhanced the catalytic activity but also d... |
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Synthesis of 3‐Iodobenzofurans by Electrophilic Cyclization under Solventless Conditions in a Ball Mill
10.1002/ejoc.201800027 2018-02-20 Under mechanochemical conditions, electrophilic cyclizations of 2‐alkynylanisoles provide 3‐iodobenzofurans in the absence of a solvent. Equimolar amounts of iodine are sufficient for achieving good yields. The eco‐friendly reaction conditions are mild, and v... |