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4-硝基苯乙醚

4-硝基苯乙醚用途

【用途一】
用作药物和染料的中间体。在医药上用于合成非那西丁等。

4-硝基苯乙醚名称

[ CAS 号 ]:
100-29-8

[ 中文名 ]:
4-硝基苯乙醚

[ 英文名 ]:
1-Ethoxy-4-nitrobenzene

[中文别名 ]:

[英文别名 ]:

4-NITROPHENETOL
1-Ethoxy-4-nitrobenzene
Ethyl p-nitrophenyl ether
4-Nitrophenetole
p-nitroethoxybenzene
EINECS 202-837-9
Ethyl 4-nitrophenyl ether
Benzene, 1-ethoxy-4-nitro-
MFCD00007330
1-Ethoxy-4-nitro-benzene

4-硝基苯乙醚物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
283.0±0.0 °C at 760 mmHg

[ 熔点 ]:
56-60 °C

[ 分子式 ]:
C₈H₉NO₃

[ 分子量 ]:
167.162

[ 闪点 ]:
134.1±21.8 °C

[ 精确质量 ]:
167.058243

[ PSA ]:
55.05000

[ LogP ]:
2.56

[ 外观性状 ]:
棕色结晶固体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.535

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸食品添加剂分开存放

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

4-硝基苯乙醚MSDS

4-硝基苯乙醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DA0600000

CHEMICAL NAME :: Benzene, 1-ethoxy-4-nitro-

CAS REGISTRY NUMBER :: 100-29-8

BEILSTEIN REFERENCE NO. :: 0972473

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C8-H9-N-O3

MOLECULAR WEIGHT :: 167.18

WISWESSER LINE NOTATION :: WNR DO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3300 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >16 gm/kg

TOXIC EFFECTS :: Liver - fatty liver degeneration Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2100 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Lungs, Thorax, or Respiration - respiratory depression Blood - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >7940 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal)

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Bacillus subtilis

DOSE/DURATION :: 5 mg/disc

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 170,11,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4374 No. of Facilities: 6 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 206 (estimated) No. of Female Employees: 23 (estimated)

4-硝基苯乙醚安全信息

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S24/25-S22

[ RTECS号 ]:
DA0600000

[ 海关编码 ]:
2909309090

4-硝基苯乙醚合成路线

4-硝基苯乙醚制备

用对硝基氯苯与乙醇在氢氧化钠参与下醚化制得。将对硝基氯苯和乙醇加到反应釜内，升温至82℃，滴加乙醇氢氧化钠溶液，在85-88℃反应3h。反应液碱度降到0.9%以下，降温至75℃，用浓盐酸将pH值调至6.7-7。静置分层后取油层，加热水洗去硝基酚钠，油层进行减压精馏，取214-218℃（2.66-5.32kpa）馏分即为本产品。

4-硝基苯乙醚海关

[ 海关编码 ]: 2909309090

[ 中文概述 ]:
2909309090 其他芳香醚及其卤化衍生物、磺化、硝化衍生物（包括亚硝化衍生物）。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%