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(4-氯苯基)[4-(8-硝基-5-喹啉基)-1-哌嗪基]甲酮

用途

SIRT2-IN-8是一种有效的SIRT2抑制剂。SIRT2-IN-8可用于亨廷顿病和帕金森病研究[1]。

名称

[ CAS 号 ]:
115687-05-3

[ 中文名 ]:
(4-氯苯基)[4-(8-硝基-5-喹啉基)-1-哌嗪基]甲酮

[ 英文名 ]:
B2

[英文别名 ]:

CPNQ
BP 554 maleate
B2

生物活性

[ 描述 ]:

SIRT2-IN-8是一种有效的SIRT2抑制剂。SIRT2-IN-8可用于亨廷顿病和帕金森病研究[1]。

[ 相关类别 ]:

信号通路 >> 表观遗传学 >> 抗衰老酶

信号通路 >> 细胞周期/DNA损伤 >> 抗衰老酶

研究领域 >> 神经疾病

[ 靶点 ]

SIRT2

[参考文献]

[1]. Bodner RA, Outeiro TF, Altmann S, et al. Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases. Proc Natl Acad Sci U S A. 2006;103(11):4246-4251.

物理化学性质

[ 密度 ]:
1.4±0.1g/cm3

[ 沸点 ]:
645.5±55.0°C at 760 mmHg

[ 分子式 ]:
C₂₀H₁₇ClN₄O₃

[ 分子量 ]:
396.83

[ 闪点 ]:
344.2±31.5°C

[ 精确质量 ]:
396.09900

[ PSA ]:
82.26000

[ LogP ]:
4.28490

[ 外观性状 ]:
solid brown

[ 折射率 ]:
1.687

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
Soluble to 100 mM in DMSO and to 10 mM in ethanol

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H315-H319-H335

[ 警示性声明 ]:
P261-P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
25-36/37/38

[ 安全声明 (欧洲) ]:
26-45

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ WGK德国 ]:
3

文献

Physicochemical characterisation of four cherry species (Prunus spp.) grown in China.

Food Chem. 173 , 855-63, (2014)

The physicochemical characteristics of four cherry species (Prunus avium, Prunus cerasus, Prunus pseudocerasus and Prunus tomentosa) were evaluated. Inter-species variability was greater than intra-sp...

The B vitamins nicotinamide (B3) and riboflavin (B2) stimulate metamorphosis in larvae of the deposit-feeding polychaete Capitella teleta: implications for a sensory ligand-gated ion channel.

PLoS ONE 9(11) , e109535, (2014)

Marine sediments can contain B vitamins, presumably incorporated from settled, decaying phytoplankton and microorganisms associated with decomposition. Because B vitamins may be advantageous for the e...

Vibration mechanosignals superimposed to resistive exercise result in baseline skeletal muscle transcriptome profiles following chronic disuse in bed rest.

Sci. Rep. 5 , 17027, (2015)

Disuse-induced muscle atrophy is a major concern in aging, in neuromuscular diseases, post-traumatic injury and in microgravity life sciences affecting health and fitness also of crew members in space...

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