2,6-二氯苯腈

2,6-二氯苯腈用途

【用途一】
是多种除草剂和杀虫剂的中间体，用于生产草克乐、除虫脲、氟幼脲等10余种农药，还用于染料、塑料等
【用途二】
2，6-二氯苯腈本身是一个除草剂品种—敌草腈，同时它也是苯甲酰脲类杀虫剂合成过程中的一个重要中间体，用于合成下一个中间体 2，6-二氟苯腈，最终得到氟铃脲、除虫脲、氟啶脲、虱螨脲等农药品种。
【用途三】
用作植物的芽前除草剂。该品对于植物有毒害的浓度很低，防除杂草对象广，药效高，毒性低。主要用于多年生禾草作物地芽前除草。还用于生产除草剂草克乐。其主要用于生产除草剂和杀虫剂的重要中间体2,6－二氟苯腈，在工程塑料、电子材料及染料等方面也有所应用。

2,6-二氯苯腈名称

[ CAS 号 ]:
1194-65-6

[ 中文名 ]:
敌草腈

[ 英文名 ]:
2,6-Dichlorobenzonitrile

[中文别名 ]:

[英文别名 ]:

2,6-DICHLOROBENZNITRILE
2,6-Dichlor-benzoesaeure-aethylester
2,6-Dichlorobenzonitrile,Dichlobenil
Casaron
Dichlobenil
EINECS 214-787-5
2,6-Dichlorobenzonitrile
Casoron G
Ethyl-2,6-dichlorbenzoat
Niagara 5996

2,6-二氯苯腈物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
279.2±20.0 °C at 760 mmHg

[ 熔点 ]:
143-146 °C(lit.)

[ 分子式 ]:
C₇H₃Cl₂N

[ 分子量 ]:
172.011

[ 闪点 ]:
126.8±16.0 °C

[ 精确质量 ]:
170.964249

[ PSA ]:
23.79000

[ LogP ]:
2.79

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.584

[ 储存条件 ]:
0-6°C

[ 水溶解性 ]:
25 mg/L (25 ºC)

2,6-二氯苯腈MSDS

详细MSDS(安全技术说明书)

2,6-二氯苯腈毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DI3500000

CHEMICAL NAME :: Benzonitrile, 2,6-dichloro-

CAS REGISTRY NUMBER :: 1194-65-6

BEILSTEIN REFERENCE NO. :: 1909167

LAST UPDATED :: 199801

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C7-H3-Cl2-N

MOLECULAR WEIGHT :: 172.01

WISWESSER LINE NOTATION :: NCR BG FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2710 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 10,97,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971 Volume(issue)/page/year: -,145,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2056 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 Volume(issue)/page/year: 5,73,1976

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - deviated nasal septum Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 15,287,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 41,41,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Liver - other changes

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 6,261,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,177,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 681 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS) Volume(issue)/page/year: -,337,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971 Volume(issue)/page/year: -,144,1971 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg/5D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - deviated nasal septum Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 15,287,1994 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 260 ug/kg/39D-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

REFERENCE :: AAATAP Annali dell'Accademia di Agricoltura di Torino. (Accademia de Agricoltura di Torino, Via Andrea Doria 10, 10123 Turin, Italy) 1870- Volume(issue)/page/year: 122,107,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 260 ug/kg/39D-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Tumorigenic - tumors at site of application

REFERENCE :: AAATAP Annali dell'Accademia di Agricoltura di Torino. (Accademia de Agricoltura di Torino, Via Andrea Doria 10, 10123 Turin, Italy) 1870- Volume(issue)/page/year: 122,107,1979 *** REVIEWS *** TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 24030 No. of Facilities: 40 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 200 (estimated)

2,6-二氯苯腈安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H312-H411

[ 警示性声明 ]:
P273-P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R21;R51/53

[ 安全声明 (欧洲) ]:
S36/37-S61

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
DI3500000

[ 包装等级 ]:
III

[ 危险类别 ]:
9

[ 海关编码 ]:
2926909090

2,6-二氯苯腈合成路线

详细合成路线

2,6-二氯苯腈上下游产品

2,6-二氯苯腈上游产品

2,6-二氯苯腈下游产品

2,6-二氯苯腈制备

2，6-二氯苯腈的制备方法较多。
2，6-二氯苯甲醛肟脱水，即 2，6-二氯苯甲醛肟加入脱水剂脱水，经冷却、结晶析出，再经过滤、洗涤、烘干，即得到 2，6-二氯苯腈。
我国目前生产上主要采用这条路线。
2，6-二氯甲苯在催化剂存在下通过氨氧化法一步制得 2，6-二氯苯腈。
这条路线反应过程大大缩短，减少了污染，并可连续化生产，降低了成本。
此外，还有其他多种合成方法，如 2，6-二氯苯甲醛或 2，6-二氯-二氯苄与羟胺反应，2，6-二氯苯胺进行重氮化、腈化反应等，都可以合成 2，6-二氯苯腈。

2,6-二氯苯腈海关

[ 海关编码 ]: 2926909090

[ 中文概述 ]:
2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

2,6-二氯苯腈文献

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Biomed Res. Int. 2015 , 381264, (2015)

The benzonitrile herbicides bromoxynil, chloroxynil, dichlobenil, and ioxynil have been used actively worldwide to control weeds in agriculture since 1970s. Even though dichlobenil is prohibited in EU...

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