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4-巯基尿苷

4-巯基尿苷用途

4-硫脲是一种核糖核苷类似物,广泛用于RNA分析和(m)RNA标记。4-硫脲抑制rRNA合成并引起核仁应激反应[1]。

4-巯基尿苷名称

[ CAS 号 ]:
13957-31-8

[ 中文名 ]:
4-硫代尿苷

[ 英文名 ]:
4-thiouridine

[中文别名 ]:

4-巯基尿苷

[英文别名 ]:

EINECS 237-735-3
4-Thio-uridin
4-Thio-D-uridine
MFCD00006538
4-thio-uridine
Uridine,4-thio
thiouridine
4-SH-Ur
THIOURIDINE,4
4-thiouridine

4-巯基尿苷生物活性

[ 描述 ]:

4-硫脲是一种核糖核苷类似物,广泛用于RNA分析和(m)RNA标记。4-硫脲抑制rRNA合成并引起核仁应激反应[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

4-硫代尿苷(0-10μM)标记并纯化新生rRNA,而不会显著影响rRNA合成[1]。4-硫尿苷(≥50μM)强烈抑制rRNA的产生和加工[1]。

[参考文献]

[1]. Burger K, et al. 4-thiouridine inhibits rRNA synthesis and causes a nucleolar stress response. RNA Biol. 2013 Oct;10(10):1623-30.

4-巯基尿苷物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 熔点 ]:
139-140℃ (ethanol )

[ 分子式 ]:
C₉H₁₂N₂O₅S

[ 分子量 ]:
260.267

[ 精确质量 ]:
260.046692

[ PSA ]:
139.80000

[ LogP ]:
-0.21

[ 外观性状 ]:
淡黄色粉末

[ 折射率 ]:
1.733

[ 储存条件 ]:
−20°C

4-巯基尿苷MSDS

4-巯基尿苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
C

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2934999090

4-巯基尿苷合成路线

4-巯基尿苷上下游产品

4-巯基尿苷上游产品

4-巯基尿苷下游产品

4-巯基尿苷海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-巯基尿苷文献

HIV-1 RNAs are Not Part of the Argonaute 2 Associated RNA Interference Pathway in Macrophages.

PLoS ONE 10 , e0132127, (2015)

MiRNAs and other small noncoding RNAs (sncRNAs) are key players in post-transcriptional gene regulation. HIV-1 derived small noncoding RNAs (sncRNAs) have been described in HIV-1 infected cells, but t...

Noncapped Alphavirus Genomic RNAs and Their Role during Infection.

J. Virol. 89 , 6080-92, (2015)

Alphaviruses are enveloped positive-sense RNA viruses that exhibit a wide host range consisting of vertebrate and invertebrate species. Previously we have reported that the infectivity of Sindbis viru...

Proteotoxic stress reprograms the chromatin landscape of SUMO modification.

Sci. Signal. 8 , rs7, (2015)

The small ubiquitin-like modifier 2 (SUMO-2) is required for survival when cells are exposed to treatments that induce proteotoxic stress by causing the accumulation of misfolded proteins. Exposure of...

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