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氨基乙基哌嗪

氨基乙基哌嗪用途

用于各种腐蚀抑制、生物活性和金属配体对分析的效果等方面的研究
医药中间体

氨基乙基哌嗪名称

[ CAS 号 ]:
140-31-8

[ 中文名 ]:
N-氨乙基哌嗪

[ 英文名 ]:
2-Piperazinoethylamine

[中文别名 ]:

[英文别名 ]:

2-piperazin-1-ylethanamine
2-Piperazinoethylamine
1-(2-Aminoethyl)piperazine
N-(2-Aminoethyl)piperazin
N-(2-Aminoethyl)piperazine
2-(1-Piperazinyl)ethanamine
Piperazine, 1- (2-aminoethyl)-
N-(β-Aminoethyl)piperazine
1-(2-aminoethyl) piperazine
2-(piperazin-1-yl)ethanamine

氨基乙基哌嗪物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
220.0±8.0 °C at 760 mmHg

[ 熔点 ]:
-19 °C

[ 分子式 ]:
C₆H₁₅N₃

[ 分子量 ]:
129.203

[ 闪点 ]:
93.3±0.0 °C

[ 精确质量 ]:
129.126602

[ PSA ]:
41.29000

[ LogP ]:
-0.86

[ 外观性状 ]:
透明液体

[ 蒸汽密度 ]:
4.4 (vs air)

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.479

[ 储存条件 ]:
库房通风低温干燥,与酸分开存放

[ 稳定性 ]:
Stable. Flammable. Incompatible with acids, acid anhydrides, acid chlorides, strong oxidizing agents, chloroformates.

[ 水溶解性 ]:
soluble

氨基乙基哌嗪MSDS

氨基乙基哌嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TK8050000

CHEMICAL NAME :: Piperazine, 1-(2-aminoethyl)-

CAS REGISTRY NUMBER :: 140-31-8

BEILSTEIN REFERENCE NO. :: 0104363

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C6-H15-N3

MOLECULAR WEIGHT :: 129.24

WISWESSER LINE NOTATION :: T6M DNTJ D2Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2140 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 880 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1680 mg/kg

SEX/DURATION :: male 28 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 500 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 320,31,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1937 No. of Facilities: 328 (estimated) No. of Industries: 11 No. of Occupations: 17 No. of Employees: 11542 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1937 No. of Facilities: 4514 (estimated) No. of Industries: 42 No. of Occupations: 41 No. of Employees: 60625 (estimated) No. of Female Employees: 12978 (estimated)

氨基乙基哌嗪安全信息

[ 符号 ]:

GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H311-H314-H317-H412

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R21/22;R34;R43;R52/53

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S61

[ 危险品运输编码 ]:
UN 2815 8/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
TK8050000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2933599090

氨基乙基哌嗪合成路线

氨基乙基哌嗪上下游产品

氨基乙基哌嗪上游产品

氨基乙基哌嗪下游产品

氨基乙基哌嗪制备

1.该品是二氯乙烷和氨反应生产乙二胺类产品时的副产品。原料消耗定额：二氯乙烷2100kg/t、液氨620kg/t、烧碱（42%）4143kg/t。

2.用二氯乙烷和氨反应制造乙二胺及多胺时所产生的副产品，经精馏、脱色后制得犖氨乙基哌嗪。

氨基乙基哌嗪海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

氨基乙基哌嗪文献

Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.

Bioorg. Med. Chem. 16 , 3530-6, (2008)

The first activation study of the human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms associated to tumors, hCA IX and XII, with a small library of natural and non-natural amino acids as well as aroma...

Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.

Bioorg. Med. Chem. Lett. 16 , 3955-9, (2006)

The first activation study of isoform XIII of carbonic anhydrase (CA, EC 4.2.1.1) is reported. A series of amino acids and amines incorporating protonatable moieties of the primary/heterocyclic amine ...

Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.

Bioorg. Med. Chem. 15 , 5351-7, (2007)

The secretory isozyme of human carbonic anhydrase (hCA, EC 4.2.1.1), hCA VI, has been cloned, expressed, and purified in a bacterial expression system. The kinetic parameters for the CO(2) hydration r...

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