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EM20-25

EM20-25名称

[ CAS 号 ]:
141266-44-6

[ 英文名 ]:
EM20-25

[英文别名 ]:

EM20-25
Bcl-2 Inhibitor III,EM20-25

EM20-25物理化学性质

[ 分子式 ]:
C₁₅H₉ClN₄O₆

[ 分子量 ]:
376.70800

[ 精确质量 ]:
376.02100

[ PSA ]:
157.72000

[ LogP ]:
1.31280

EM20-25MSDS

EM20-25安全信息

[ 符号 ]:

GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H400

[ 警示性声明 ]:
P273

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

EM20-25合成路线

EM20-25上下游产品

EM20-25上游产品

EM20-25下游产品

EM20-25文献

Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization.

PLoS ONE 5(3) , e9924, (2010)

Current limitations of chemotherapy include toxicity on healthy tissues and multidrug resistance of malignant cells. A number of recent anti-cancer strategies aim at targeting the mitochondrial apopto...

The mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative.

J. Biol. Chem. 281 , 10066-10072, (2006)

We have investigated the mitochondrial effects of BH3I-2', Chelerythrine, and HA14-1, small organic molecules that share the ability to bind the BH3 domain of BCL-2. All compounds displayed a biphasic...

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