磺胺间二甲氧嘧啶
磺胺间二甲氧嘧啶用途
磺胺间二甲氧嘧啶名称
[ CAS 号 ]:
155-91-9
[ 中文名 ]:
磺胺间二甲氧嘧啶
[ 英文名 ]:
Sulphamoprine
[英文别名 ]:
- Sulfanilsaeure-(4,6-dimethoxy-pyrimidin-2-ylamid)
- Sulphamoprine
- Sulfadimethoxypyrimidine
- sulphadimethoxine
- sulfadimethoxine
- SDmP
- Sulfamoprine
- ICI 3435
- Sulphadimethoxypyrimidine
磺胺间二甲氧嘧啶物理化学性质
[ 密度 ]:
1.4±0.1 g/cm3
[ 沸点 ]:
570.7±60.0 °C at 760 mmHg
[ 熔点 ]:
200ºC
[ 分子式 ]:
C12H14N4O4S
[ 分子量 ]:
310.329
[ 闪点 ]:
298.9±32.9 °C
[ 精确质量 ]:
310.073578
[ PSA ]:
124.81000
[ LogP ]:
1.41
[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C
[ 折射率 ]:
1.623
磺胺间二甲氧嘧啶毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DA9495000
- CHEMICAL NAME :
- Benzenesulfonamide, 4-amino-N-(4,6-dimethoxy-2-pyrimidinyl)-
- CAS REGISTRY NUMBER :
- 155-91-9
- BEILSTEIN REFERENCE NO. :
- 0307123
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C12-H14-N4-O4-S
- MOLECULAR WEIGHT :
- 310.36
- WISWESSER LINE NOTATION :
- T6N CNJ BMSWR DZ& DO1 FO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 28 gm/kg/28D-I
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), zonal Blood - normocytic anemia Related to Chronic Data - death
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 2,149,1947 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 538 mg/kg
- SEX/DURATION :
- female 1-22 day(s) after conception lactating female 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Effects on Newborn - physical
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 23,305,1964
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1 gm/kg
- SEX/DURATION :
- female 14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - stillbirth
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 23,305,1964
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 825 mg/kg
- SEX/DURATION :
- female 1-22 day(s) after conception lactating female 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 23,305,1964
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 500 mg/kg
- SEX/DURATION :
- female 11-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - skin and skin appendages
- REFERENCE :
- EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 21,151,1965
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2520 mg/kg
- SEX/DURATION :
- female 1-22 day(s) after conception lactating female 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 23,305,1964
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2520 mg/kg
- SEX/DURATION :
- female 1-22 day(s) after conception lactating female 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 23,305,1964
磺胺间二甲氧嘧啶安全信息
[ 危害码 (欧洲) ]:
Xi
[ 风险声明 (欧洲) ]:
36/37/38-43
[ 安全声明 (欧洲) ]:
26-36/37-24/25-23
[ 海关编码 ]:
2935009090
磺胺间二甲氧嘧啶合成路线
磺胺间二甲氧嘧啶上下游产品
磺胺间二甲氧嘧啶上游产品
磺胺间二甲氧嘧啶下游产品
磺胺间二甲氧嘧啶海关
[ 海关编码 ]: 2935009090
[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%
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