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4-甲酰氨基-1,2-二氢-1,5-二甲基-2-苯基-3H-吡唑-3-酮

用途

4-Formylaminoantipyrine 是氨基苯那酮的排泄代谢物 (metabolite)。Aminophenazone 是一种具有镇痛、抗炎、解热作用的吡唑啉酮。

名称

[ CAS 号 ]:
1672-58-8

[ 中文名 ]:
4-甲酰氨基安替吡啉

[ 英文名 ]:
4-Formamidoantipyrine

[中文别名 ]:

[英文别名 ]:

4-Formylaminoantipyrine
4-Formamidoantipyrine
Formamide,N-antipyrinyl
4-formyl-aminoantipyrin
4-formaminoantipyrine
N-Formyl-4-aminoantipyrine

生物活性

[ 描述 ]:

4-Formylaminoantipyrine 是氨基苯那酮的排泄代谢物 (metabolite)。Aminophenazone 是一种具有镇痛、抗炎、解热作用的吡唑啉酮。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[参考文献]

[1]. M Levy, et al. Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis B virus. Clin Pharmacol Ther

[2]. A Noda, et al.Formation of 4-formylaminoantipyrine as a new metabolite of aminopyrine. II. Enzymatic demethylation and oxidation of aminopyrine and 4-monomethylaminoantipyrine. Chem Pharm Bull (Tokyo).1976 Dec;24(12):3229-31.

[3]. David do C Malvar, et al. Dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2 -dependent and -independent fever while 4-AA only blocks PGE2 -dependent fever. Br J Pharmacol. 2014 Aug;171(15):3666-79.

物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
374.5±52.0 °C at 760 mmHg

[ 熔点 ]:
189-192ºC

[ 分子式 ]:
C₁₂H₁₃N₃O₂

[ 分子量 ]:
231.251

[ 闪点 ]:
180.3±30.7 °C

[ 精确质量 ]:
231.100784

[ PSA ]:
56.03000

[ LogP ]:
0.41

[ 外观性状 ]:
固体;White to Orange to Green powder to crystal

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.609

[ 储存条件 ]:
Refrigerator

MSDS

安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
20/22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933199090

合成路线

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[ 海关编码 ]: 2933199090

[ 中文概述 ]:
2933199090. 其他结构上有非稠合吡唑环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

文献

High-performance liquid chromatographic assay for metamizol metabolites in rat plasma: application to pharmacokinetic studies.

J. Pharm. Biomed. Anal. 71 , 173-8, (2012)

In order to evaluate the pharmacokinetics of metamizol in the presence of morphine in arthritic rats, after subcutaneous administration of the drugs, an easy, rapid, sensitive and selective analytical...

Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis-B virus does not occur in rapid acetylators.

Eur. J. Clin. Pharmacol. 57(6-7) , 461-5, (2001)

We previously found that, compared with healthy subjects. asymptomatic hepatitis-B virus (HBV) carriers displaying slow acetylator phenotype demonstrate a significant prolongation of the elimination h...

Simple high-performance liquid chromatographic method for simultaneous determination of aminopyrine and its metabolites.

J. Chromatogr. A. 421(1) , 198-205, (1987)

更多文献

4-甲酰氨基-1,2-二氢-1,5-二甲基-2-苯基-3H-吡唑-3-酮

用途

名称

生物活性

物理化学性质

MSDS

详细MSDS(安全技术说明书)

安全信息

合成路线

详细合成路线

上下游产品

上游产品

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海关

文献

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