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氰基硼氘化钠

氰基硼氘化钠用途

氰基硼氢化钠-d3是氘标记的氰基硼氯化钠[1]。

氰基硼氘化钠名称

[ CAS 号 ]:
25895-62-9

[ 中文名 ]:
氰基硼氘化钠

[ 英文名 ]:
sodium cyanoborodeuteride

[英文别名 ]:

MFCD00003517
Sodium cyanoborodeuteride

氰基硼氘化钠生物活性

[ 描述 ]:

氰基硼氢化钠-d3是氘标记的氰基硼氯化钠[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要作为药物开发过程中定量的示踪剂。头韵因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

氰基硼氘化钠物理化学性质

[ 熔点 ]:
>242ºC (dec.)(lit.)

[ 分子式 ]:
CBD₃NNa

[ 分子量 ]:
65.86050

[ 精确质量 ]:
66.04450

[ PSA ]:
23.79000

[ 外观性状 ]:
白色至淡黄色结晶粉末

[ 储存条件 ]:
Poison room

氰基硼氘化钠MSDS

详细MSDS(安全技术说明书)

氰基硼氘化钠安全信息

[ 符号 ]:

GHS02, GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H228-H300 + H310 + H330-H314

[ 警示性声明 ]:
P210-P260-P264-P280-P284-P301 + P310

[ 危害码 (欧洲) ]:
F: Flammable;T+: Very toxic;

[ 风险声明 (欧洲) ]:
R11

[ 安全声明 (欧洲) ]:
16-26-36/37/39-45 25 28A 7 8

[ 危险品运输编码 ]:
UN 2926 4

[ WGK德国 ]:
3

[ 包装等级 ]:
II

[ 危险类别 ]:
4.3

氰基硼氘化钠文献

SPECHT - single-stage phosphopeptide enrichment and stable-isotope chemical tagging: quantitative phosphoproteomics of insulin action in muscle.

J. Proteomics 114 , 48-60, (2015)

The study of cellular signaling remains a significant challenge for translational and clinical research. In particular, robust and accurate methods for quantitative phosphoproteomics in tissues and tu...

Mass spectrometry based quantitative proteomics and integrative network analysis accentuates modulating roles of annexin-1 in mammary tumorigenesis.

Proteomics 15(2-3) , 408-18, (2015)

Annexin-1 (ANXA1) is known to be involved in important cellular processes and implicated in cancer. Our previous study showed its roles in cell migration and DNA-damage response processes in breast ca...

Impact of cathepsin B on the interstitial fluid proteome of murine breast cancers.

Biochimie 122 , 88-98, (2016)

Carcinomas establish a molecular cross talk between malignant tumor cells and the activated non-malignant cells of the tumor stroma. This cell-cell communication in tumor-stroma interaction includes s...

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