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12-冠醚-4

12-冠醚-4名称

[ CAS 号 ]:
294-93-9

[ 中文名 ]:
12-冠醚-4

[ 英文名 ]:
12-Crown-4

[中文别名 ]:

[英文别名 ]:

12-crown-4 ether
ethylene oxide cyclic tetramer
1,4,7,10-Tetraoxacyclododecane
12-Crown 4-Ether
12-Crown-4
12-Crown-4-ether
1,4,7,10-tetraoxa-cyclododecane
EINECS 206-036-5
UNII-K6069P2C2A
EOCT

12-冠醚-4物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
254.9±0.0 °C at 760 mmHg

[ 熔点 ]:
16 °C(lit.)

[ 分子式 ]:
C₈H₁₆O₄

[ 分子量 ]:
176.210

[ 闪点 ]:
120.1±30.0 °C

[ 精确质量 ]:
176.104858

[ PSA ]:
36.92000

[ LogP ]:
-0.54

[ 外观性状 ]:
透明液体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.404

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
MISCIBLE

12-冠醚-4MSDS

详细MSDS(安全技术说明书)

12-冠醚-4毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XF0550000

CHEMICAL NAME :: 1,4,7,10-Tetraoxacyclododecane

CAS REGISTRY NUMBER :: 294-93-9

BEILSTEIN REFERENCE NO. :: 1363064

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C8-H16-O4

MOLECULAR WEIGHT :: 176.24

WISWESSER LINE NOTATION :: T-12-O DO GO JOTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2830 mg/kg

TOXIC EFFECTS :: Behavioral - tremor

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 1,339,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1550 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3150 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 44,263,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1290 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4530 uL/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536186 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1 ppm/7H

SEX/DURATION :: male 15 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 27,342,1974

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 500 ppb/7H

SEX/DURATION :: male 15 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 27,342,1974

12-冠醚-4安全信息

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22;R36/37/38

[ 安全声明 (欧洲) ]:
S28-S36/37-S45-S36-S26

[ 危险品运输编码 ]:
UN 2810

[ WGK德国 ]:
3

[ RTECS号 ]:
XF0550000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29329995

12-冠醚-4合成路线

详细合成路线

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12-冠醚-4海关

[ 海关编码 ]: 29329995