L-Leucine,N-acetyl-4-[bis(2-chloroethyl)amino]phenylalanyl-, ethyl ester

名称

[ CAS 号 ]:
3577-89-7

[ 英文名 ]:
L-Leucine,N-acetyl-4-[bis(2-chloroethyl)amino]phenylalanyl-, ethyl ester

[英文别名 ]:

leucine sarcolysine
Asaley
Asalex
Ethyl ester of N-acetyl-DL-sarcolysyl-L-leucine

物理化学性质

[ 密度 ]:
1.179g/cm3

[ 沸点 ]:
686.7ºC at 760mmHg

[ 分子式 ]:
C₂₃H₃₅Cl₂N₃O₄

[ 分子量 ]:
488.44800

[ 闪点 ]:
369.1ºC

[ 精确质量 ]:
487.20000

[ PSA ]:
87.74000

[ LogP ]:
3.89360

[ 折射率 ]:
1.535

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OH2900000

CHEMICAL NAME :: Leucine, N-(N-acetyl-3-(p-(bis(2-chloroethyl)amino)phenyl)-DL- alanyl)-, ethyl ester, L-

CAS REGISTRY NUMBER :: 3577-89-7

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C23-H35-Cl2-N3-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 680 mg/kg/10D-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 33,472,1970

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 215 mg/kg/10D-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 33,472,1970

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Rectal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 590 mg/kg/10D-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 33,472,1970