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间氟-DL-酪氨酸

间氟-DL-酪氨酸用途

2-氨基-3-(3-氟-4-羟基苯基)丙酸是一种酪氨酸衍生物[1]。

间氟-DL-酪氨酸名称

[ CAS 号 ]:
403-90-7

[ 中文名 ]:
间氟-DL-酪氨酸

[ 英文名 ]:
Tyrosine, 3-fluoro-

[中文别名 ]:

3-氟-DL-酪氨酸

[英文别名 ]:

2-Amino-3-(3-fluoro-4-hydroxyphenyl)propanoic acid
MFCD00063075
FLUORTHYRIN
PARDINON
DL-M-FLUOROTYROSINE
ba2745
DL-3-FLUOROTYROSINE
m-fluorotyrosine
m-ftyr
H-3-FLUORO-DL-TYR-OH

间氟-DL-酪氨酸生物活性

[ 描述 ]:

2-氨基-3-(3-氟-4-羟基苯基)丙酸是一种酪氨酸衍生物[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

氨基酸和氨基酸衍生物已被商业化用作能量补充剂。它们影响合成代谢激素的分泌、运动期间的燃料供应、压力相关任务期间的精神表现,并防止运动引起的肌肉损伤。它们被认为是有益的能生膳食物质[1]。

[参考文献]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

间氟-DL-酪氨酸物理化学性质

[ 密度 ]:
1.421g/cm3

[ 沸点 ]:
362.4ºC at 760mmHg

[ 熔点 ]:
276-280ºC

[ 分子式 ]:
C₉H₁₀FNO₃

[ 分子量 ]:
199.17900

[ 闪点 ]:
172.9ºC

[ 精确质量 ]:
199.06400

[ PSA ]:
83.55000

[ LogP ]:
1.18600

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
6.94E-06mmHg at 25°C

[ 折射率 ]:
1.591

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with strong reducing agents, strong oxidizing agents.

间氟-DL-酪氨酸MSDS

间氟-DL-酪氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YP2660000

CHEMICAL NAME :: Tyrosine, 3-fluoro-, DL-

CAS REGISTRY NUMBER :: 403-90-7

BEILSTEIN REFERENCE NO. :: 3204804

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H10-F-N-O3

MOLECULAR WEIGHT :: 199.20

WISWESSER LINE NOTATION :: QVYZ1R DQ CF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 68,1671,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9900 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 155,135,1967

间氟-DL-酪氨酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn,T

[ 风险声明 (欧洲) ]:
20/21/22

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
UN 3276

[ WGK德国 ]:
3

[ RTECS号 ]:
YP2660000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2922509090

间氟-DL-酪氨酸合成路线

间氟-DL-酪氨酸上下游产品

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间氟-DL-酪氨酸海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

间氟-DL-酪氨酸文献

Aminoacrylate intermediates in the reaction of Citrobacter freundii tyrosine phenol-lyase.

Biochemistry 45(31) , 9575-83, (2006)

Tyrosine phenol-lyase (TPL) from Citrobacter freundii is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the reversible hydrolytic cleavage of l-Tyr to give phenol and ammonium pyruvate...

Hydrogen bonding in human manganese superoxide dismutase containing 3-fluorotyrosine.

Biophys. J. 89(6) , 4171-9, (2005)

Incorporation of 3-fluorotyrosine and site-specific mutagenesis has been utilized with Fourier transform infrared (FTIR) spectroscopy and x-ray crystallography to elucidate active-site structure and t...

Conformational changes in the crystal structure of rat glutathione transferase M1-1 with global substitution of 3-fluorotyrosine for tyrosine.

J. Mol. Biol. 281(2) , 323-39, (1998)

The structure of the tetradeca-(3-fluorotyrosyl) M1-1 GSH transferase (3-FTyr GSH transferase), a protein in which tyrosine residues are globally substituted by 3-fluorotyrosines has been determined a...

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