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D-甲状腺素

D-甲状腺素用途

D-甲状腺素(D-T4)是一种可以抑制TSH分泌的甲状腺激素。D-甲状腺素可用于研究高胆固醇血症[1][2]。

D-甲状腺素名称

[ CAS 号 ]:
51-49-0

[ 中文名 ]:
D-甲状腺素

[ 英文名 ]:
Dextrothyroxine

[中文别名 ]:

右旋甲状腺素

[英文别名 ]:

EINECS 200-102-7
D-Thyroxine
MFCD00063056
Choloxin
Thyroxine
3,3′,5,5″-Tetraiodo-D-thyronine

D-甲状腺素生物活性

[ 描述 ]:

D-甲状腺素(D-T4)是一种可以抑制TSH分泌的甲状腺激素。D-甲状腺素可用于研究高胆固醇血症[1][2]。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[参考文献]

[1]. Bantle JP, et, al. Comparison of effectiveness of thyrotropin-suppressive doses of D- and L-thyroxine in treatment of hypercholesterolemia. Am J Med. 1984 Sep;77(3):475-81.

[2]. Gless KH, et, al. Influence of D-thyroxine on plasma thyroid hormone levels and TSH secretion. Horm Metab Res. 1977 Jan;9(1):69-73.

D-甲状腺素物理化学性质

[ 密度 ]:
2.6±0.1 g/cm3

[ 沸点 ]:
576.3±50.0 °C at 760 mmHg

[ 熔点 ]:
225ºC

[ 分子式 ]:
C₁₅H₁₁I₄NO₄

[ 分子量 ]:
776.870

[ 闪点 ]:
302.3±30.1 °C

[ 精确质量 ]:
776.686646

[ PSA ]:
92.78000

[ LogP ]:
5.93

[ 外观性状 ]:
奶油色固体

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.795

[ 储存条件 ]:
2-8°C

D-甲状腺素MSDS

D-甲状腺素安全信息

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S24/25

[ WGK德国 ]:
3

[ 海关编码 ]:
2922509090

D-甲状腺素合成路线

D-甲状腺素上下游产品

D-甲状腺素上游产品

D-甲状腺素下游产品

D-甲状腺素制备

可从动物甲状腺中提取。可由3,5-二碘-L-酪氨酸为原料制取。

D-甲状腺素海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

D-甲状腺素文献

Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.

J. Med. Chem. 50 , 5589-99, (2007)

Transthyretin (TTR), a tetrameric thyroxine (T4) carrier protein, is associated with a variety of amyloid diseases. In this study, we explore the potential of biphenyl ethers (BPE), which are shown to...

Maintenance of brain thyroid hormone level during peripheral hypothyroid condition in adult rat.

Life Sci. 79(15) , 1450-5, (2006)

Thyroid hormones are essential for normal functioning of adult mammalian brain. The present investigation deals with the understanding of the time course of thyroid hormone homeostasis in adult rat br...

Dextrothyroxine in the treatment of generalized thyroid hormone resistance in a boy homozygous for a defect in the T3 receptor.

Thyroid 2(1) , 15-9, (1992)

The dextroisomer of thyroxine (D-T4) has been shown to have suppressive effects on pituitary TSH secretion in euthyroid individuals and patients with mild thyroid hormone resistance. We treated a 3-ye...

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