三甲卡因
三甲卡因名称
[ CAS 号 ]:
616-68-2
[ 中文名 ]:
三甲卡因
[ 英文名 ]:
trimecaine
[中文别名 ]:
[英文别名 ]:
- Justecaina
- Trimecain
- Mesidicain
- trimecaine
- Mesokain
- N,N-Diethyl-N-mesitylglycinamide
- 2-Diethylaminoacetyl-2',4',6'-trimethylanilide
- Mesidicaine
- N-sym-Trimethylphenyldiethylaminoacetamide
- Diethylglycinemesidide
三甲卡因物理化学性质
[ 密度 ]:
1.0±0.1 g/cm3
[ 沸点 ]:
360.3±30.0 °C at 760 mmHg
[ 熔点 ]:
44°
[ 分子式 ]:
C15H24N2O
[ 分子量 ]:
248.364
[ 闪点 ]:
171.7±24.6 °C
[ 精确质量 ]:
248.188858
[ PSA ]:
32.34000
[ LogP ]:
2.82
[ 外观性状 ]:
白色结晶粉末
[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C
[ 折射率 ]:
1.544
三甲卡因毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AE2075000
- CHEMICAL NAME :
- Acetanilide, 2-(diethylamino)-2',4',6'-trimethyl-
- CAS REGISTRY NUMBER :
- 616-68-2
- BEILSTEIN REFERENCE NO. :
- 2697351
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C15-H24-N2-O
- MOLECULAR WEIGHT :
- 248.41
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 180 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 23,222,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 295 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 48,402,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 187 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 50,112,1987
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 129 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 39,426,1976
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