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二辛酰乙二醇

二辛酰乙二醇用途

二辛基乙二醇(乙二醇二丙酸酯)是一种二酰基甘油类似物,是一种二酰基甘油激酶(DGK)抑制剂(Ki为58μM)[1]。

二辛酰乙二醇名称

[ CAS 号 ]:
627-86-1

[ 中文名 ]:
亚乙基乙二醇二辛酸酯

[ 英文名 ]:
Octanoic acid,1,1'-(1,2-ethanediyl) ester

[中文别名 ]:

1,2-二辛基亚乙基乙二醇

[英文别名 ]:

2-octanoyloxyethyl octanoate
MFCD00058489

二辛酰乙二醇生物活性

[ 描述 ]:

二辛基乙二醇(乙二醇二丙酸酯)是一种二酰基甘油类似物,是一种二酰基甘油激酶(DGK)抑制剂(Ki为58μM)[1]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 其他

[体外研究]

二辛烷基乙二醇(二辛烷基乙二醇)抑制血小板中的二酰甘油磷酸化(100μM时为70-100%),从而产生寿命更长的二酰甘油信号[1]。

[参考文献]

[1]. W R Bishop, et al. Attenuation of sn-1,2-diacylglycerol second messengers by diacylglycerol kinase. Inhibition by diacylglycerol analogs in vitro and in human platelets. J Biol Chem. 1986 May 25;261(15):6993-7000.

二辛酰乙二醇物理化学性质

[ 密度 ]:
0.945g/cm3

[ 沸点 ]:
387.1ºC at 760 mmHg

[ 分子式 ]:
C₁₈H₃₄O₄

[ 分子量 ]:
314.46000

[ 闪点 ]:
179.8ºC

[ 精确质量 ]:
314.24600

[ PSA ]:
52.60000

[ LogP ]:
4.79380

[ 折射率 ]:
1.447

[ 储存条件 ]:
-20°C

二辛酰乙二醇MSDS

二辛酰乙二醇安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2915900090

二辛酰乙二醇合成路线

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二辛酰乙二醇海关

[ 海关编码 ]: 2915900090

[ 中文概述 ]:
2915900090. 其他饱和无环一元羧酸及其酸酐（酰卤、过氧）化物、过氧酸及其卤化、硝化、磺化、亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

二辛酰乙二醇文献

Attenuation of sn-1,2-diacylglycerol second messengers by diacylglycerol kinase. Inhibition by diacylglycerol analogs in vitro and in human platelets.

J. Biol. Chem. 261 , 6993, (1986)

Diacylglycerol kinase is though to play a central role in the metabolism of diacylglycerol second messengers in agonist-stimulated cells. A series of diacylglycerol analogs were tested for their abili...

Peroxides of vanadate induce activation of phospholipase D in HL-60 cells. Role of tyrosine phosphorylation.

J. Biol. Chem. 267(17) , 11908-16, (1992)

To determine the role of protein tyrosine phosphorylation in the activation of phospholipase D (PLD), electropermeabilized HL-60 cells labeled in [3H]alkyl-phosphatidylcholine were treated with vanada...

Phosphocholine transferase is more efficient than diacylglycerol kinase as possible attenuator of diacylglycerol signals in primordial human placenta.

Acta Physiol. Hung. 81(4) , 341-54, (1993)

Diacylglycerols (DAG) are assumed to play intracellular signal roles in rapidly growing tissues like those present in the primordial human placenta. The aim of the present study was to gain informatio...

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