<生产厂家价格>

硫代乙酰苯胺

硫代乙酰苯胺用途

Thioacetanilide, purinylthioacetanilides derivative is being researched as a potent HIV-1 NNRTI.

硫代乙酰苯胺名称

[ CAS 号 ]:
637-53-6

[ 中文名 ]:
硫代乙酰苯胺

[ 英文名 ]:
Thioacetanilide

[中文别名 ]:

[英文别名 ]:

MFCD00004942
N-phenylethanethioamide
EINECS 211-288-4

硫代乙酰苯胺物理化学性质

[ 密度 ]:
1.16g/cm3

[ 沸点 ]:
147 °C / 1mmHg

[ 熔点 ]:
76-79 °C(lit.)

[ 分子式 ]:
C₈H₉NS

[ 分子量 ]:
151.22900

[ 闪点 ]:
89.95ºC

[ 精确质量 ]:
151.04600

[ PSA ]:
44.12000

[ LogP ]:
2.51880

[ 外观性状 ]:
固体;White to Gray to Brown powder to crystal

[ 折射率 ]:
1.654

[ 储存条件 ]:
室温

硫代乙酰苯胺MSDS

硫代乙酰苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AE7350000

CHEMICAL NAME :: Acetanilide, thio-

CAS REGISTRY NUMBER :: 637-53-6

BEILSTEIN REFERENCE NO. :: 2205727

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C8-H9-N-S

MOLECULAR WEIGHT :: 151.24

WISWESSER LINE NOTATION :: SUY1&MR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2635 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(2),72,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2625 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(2),72,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1775 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(2),72,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1820 mg/kg/26W-I

TOXIC EFFECTS :: Brain and Coverings - changes in brain weight Blood - pigmented or nucleated red blood cells Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(2),72,1986

硫代乙酰苯胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H312 + H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R20/21

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AE7350000

[ 海关编码 ]:
2930909090

硫代乙酰苯胺合成路线

硫代乙酰苯胺海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

硫代乙酰苯胺文献

The metabolism of thioacetanilide in the rat.

Xenobiotica 13(8) , 475-82, (1983)

The metabolism and acute toxicity of thioacetanilide was studied in the rat. Following intragastric dosage (100 mg/kg), over 90% dose was excreted in urine, predominantly as conjugated metabolites: le...

1,2,3-Selenadiazole thioacetanilides: synthesis and anti-HIV activity evaluation.

Bioorg. Med. Chem. 17(17) , 6374-9, (2009)

The development of new HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) offers the possibility of generating novel structures of increased potency. Based on the bioisosteric principle, n...

Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

Bioorg. Med. Chem. 17(16) , 5775-81, (2009)

A series of 2-(1-aryl-1H-imidazol-2-ylthio)acetamide [imidazole thioacetanilide (ITA)] derivatives were synthesized and evaluated as potent inhibitors of human immunodeficiency virus type-1 (HIV-1). A...

更多文献