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双(对硝基苯基)磷酸酯

双(对硝基苯基)磷酸酯用途

【用途一】
用作三氮唑核苷的催化剂
【用途二】
磷酸二酯酶的底物（Phosphodiesterase Substrate）。

双(对硝基苯基)磷酸酯名称

[ CAS 号 ]:
645-15-8

[ 中文名 ]:
双(对硝基苯基)磷酸酯

[ 英文名 ]:
Bis(4-nitrophenyl) phosphate

[中文别名 ]:

[英文别名 ]:

Bis(4-nitrophenyl)phosphate
p-nitro-phenohydrogenphosphate
bnpp
Phosphoric acid, bis(4-nitrophenyl) ester
MFCD00007318
Phosphoric acid, bis(p-nitrophenyl) ester
Di-p-nitrophenyl phosphate
Bis(4-nitrophenyl) hydrogen phosphate
Di-4-nitrophenyl phosphate
Bis(p-nitrophenyl)phosphate

双(对硝基苯基)磷酸酯物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
545.7±60.0 °C at 760 mmHg

[ 熔点 ]:
172-175 °C(lit.)

[ 分子式 ]:
C₁₂H₉N₂O₈P

[ 分子量 ]:
340.182

[ 闪点 ]:
283.8±32.9 °C

[ 精确质量 ]:
340.009644

[ PSA ]:
157.21000

[ LogP ]:
1.70

[ 外观性状 ]:
类白色或淡黄色结晶粉末

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.642

[ 储存条件 ]:
通风,干燥,防晒

双(对硝基苯基)磷酸酯MSDS

双(对硝基苯基)磷酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TB8260000

CHEMICAL NAME :: Phosphoric acid, bis(p-nitrophenyl) ester

CAS REGISTRY NUMBER :: 645-15-8

BEILSTEIN REFERENCE NO. :: 2064857

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C12-H9-N2-O8-P

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 410 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HSZPAZ Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie. (Walter de Gruyter, Inc., 200 Saw Mill River Rd., Hawthorne, NY 10532) V.21- 1895/96- Volume(issue)/page/year: 348,609,1967 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9818 No. of Facilities: 72 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1005 (estimated) No. of Female Employees: 698 (estimated)

双(对硝基苯基)磷酸酯安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300

[ 警示性声明 ]:
P264-P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
S45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
TB8260000

双(对硝基苯基)磷酸酯合成路线

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双(对硝基苯基)磷酸酯文献

Characterization of Species Differences in Tissue Diltiazem Deacetylation Identifies Ces2a as a Rat-Specific Diltiazem Deacetylase.

Drug Metab. Dispos. 43 , 1218-25, (2015)

Diltiazem, a calcium channel blocker, is mainly metabolized via demethylation or deacetylation in humans. Diltiazem demethylation is catalyzed by cytochrome P450 2D6 and 3A4. Although it was previousl...

Screening of stabilizers for LC-MS/MS analysis of clevidipine and its primary metabolite in dog whole blood.

Bioanalysis 7 , 1457-69, (2015)

Clevidipine is an ester-containing antihypertensive agent that undergoes rapid hydrolysis in blood. A reliable stabilizer cocktail containing citric acid and ascorbic acid was established and the LC-M...

Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation.

J. Pharmacol. Exp. Ther. 344(3) , 665-72, (2013)

Clopidogrel pharmacotherapy is associated with substantial interindividual variability in clinical response, which can translate into an increased risk of adverse outcomes. Clopidogrel, a recognized s...

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