松蕈酸

松蕈酸用途

Agaric acid (Agaricinic Acid) 来自真菌部落的 Polyporus officinalis 和 Polyporus igniarius。Agaric acid 通过其与腺嘌呤核苷酸转位酶的相互作用诱导线粒体通透性转变。Agaric acid 可促进积累的 Ca2+ 流出,跨膜电位的破坏和线粒体肿胀。Agaric acid 用于调节脂类代谢。

松蕈酸名称

[ CAS 号 ]:
666-99-9

[ 中文名 ]:
伞菌酸水合物

[ 英文名 ]:
agaric acid

[中文别名 ]:

松蕈酸

[英文别名 ]:

Laricic acid
n-Hexadecylcitric acid
EINECS 211-566-5
Agaricinic acid
(2S,3S)-2-Hydroxy-nonadecan-1,2,3-tricarbonsaeure
Lr-2-Hydroxy-nonadecan-1,2rF,3cF-tricarbonsaeure
Agaric acid
Agaricinsaeure
MFCD00002665
Agaricin

松蕈酸生物活性

[ 描述 ]:

[参考文献]

[1]. García N, et al. Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Its dependence on membrane fluidity. Mitochondrion. 2005 Aug;5(4):272-81.

松蕈酸物理化学性质

[ 密度 ]:
1.115g/cm3

[ 沸点 ]:
509.3ºC at 760 mmHg

[ 熔点 ]:
142° (dec)

[ 分子式 ]:
C₂₂H₄₀O₇

[ 分子量 ]:
416.54900

[ 闪点 ]:
275.9ºC

[ 精确质量 ]:
416.27700

[ PSA ]:
132.13000

[ LogP ]:
4.84900

[ 外观性状 ]:
固体

[ 折射率 ]:
1.501

[ 储存条件 ]:
室温

松蕈酸MSDS

详细MSDS(安全技术说明书)

松蕈酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RA5365000

CHEMICAL NAME :: 1,2,3-Nonadecanetricarboxylic acid, 2-hydroxy-

CAS REGISTRY NUMBER :: 666-99-9

BEILSTEIN REFERENCE NO. :: 1729981

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H40-O7

MOLECULAR WEIGHT :: 416.62

WISWESSER LINE NOTATION :: QVY16&XQVQ1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935

松蕈酸安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
RA5365000

松蕈酸上下游产品

松蕈酸上游产品

松蕈酸下游产品

松蕈酸文献

Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Its dependence on membrane fluidity.

Mitochondrion 5 , 272-281, (2005)

The effect of agaric acid as inducer of mitochondrial permeability transition was studied. It was found that: (i) agaric acid (AA) promoted efflux of accumulated Ca2+, collapse of transmembrane potent...

The mechanisms of fatty acid-induced proton permeability of the inner mitochondrial membrane.

J. Bioenerg. Biomembr. 31 , 447-455, (1999)

Nonesterified long-chain fatty acids have long been known as uncouplers of oxidative phosphorylation. They are efficient protonophores in the inner mitochondrial membrane but not so in artificial phos...

The effect of N-ethylmaleimide on permeability transition as induced by carboxyatractyloside, agaric acid, and oleate.

Cell Biochem. Biophys. 51 , 81-87, (2008)

In this work, we studied the effect of N-ethylmaleimide on permeability transition. The findings indicate that the amine inhibited the effects of carboxyatractyloside and agaric acid. It is known that...

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松蕈酸