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5β-Pregnane-3α,17α,21-triol-20-one

用途

四氢-11-脱氧皮质醇(四氢脱氧皮质醇)是尿中存在的内源性代谢产物,可用于11β羟化酶缺乏症的研究[1][2]。

名称

[ CAS 号 ]:
68-60-0

[ 中文名 ]:
5β-Pregnane-3α,17α,21-triol-20-one

[ 英文名 ]:
Tetrahydro-11-deoxy Cortisol

[英文别名 ]:

tetrahydrocortexolone
5beta-Pregnane-3alpha,17alpha,21-triol-20-one
3alpha,17alpha,21-Trihydroxy-5beta-pregnan-20-one
EINECS 200-691-0
Tetrahydrodeoxycortisol
Tetrahydro-11-deoxycortisol

生物活性

[ 描述 ]:

四氢-11-脱氧皮质醇(四氢脱氧皮质醇)是尿中存在的内源性代谢产物,可用于11β羟化酶缺乏症的研究[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

[体外研究]

内源性代谢产物被定义为《京都基因和基因组百科全书》注释为我们基因组中约1900种代谢酶的底物或产物。在文献正文中很清楚,许多这些代谢产物都具有毒性[1]。

[参考文献]

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

[2]. Burren CP, et al. CYP11 beta 1 (11-beta-hydroxylase) deficiency in congenital adrenal hyperplasia. J Paediatr Child Health. 1996 Oct;32(5):433-8.

物理化学性质

[ 密度 ]:
1.186g/cm3

[ 沸点 ]:
505.1ºC at 760 mmHg

[ 分子式 ]:
C₂₁H₃₄O₄

[ 分子量 ]:
350.49200

[ 闪点 ]:
273.4ºC

[ 精确质量 ]:
350.24600

[ PSA ]:
77.76000

[ LogP ]:
2.68250

[ 折射率 ]:
1.56

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

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文献

Study of urinary steroid hormone disorders: difference between hepatocellular carcinoma in early stage and cirrhosis.

Anal. Bioanal. Chem 406(18) , 4325-35, (2014)

Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world. Discovery of novel biomarkers for early HCC from other liver diseases such as cirrhosis is of great clinical benefit. In th...

[Urinary tetrahydro-11-deoxycortisol].

Nihon Rinsho. 68 Suppl 7 , 401-3, (2010)

A quantitative in vivo mouse model used to assay inhibitors of tumor-induced angiogenesis.

Cancer Res. 51(4) , 1339-44, (1991)

An in vivo model of tumor-induced angiogenesis was used to monitor two known inhibitors of angiogenesis, protamine sulfate and the steroid tetrahydro S. Tumor cells entrapped in alginate beads were in...

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